Abstract
Introduction: The female genital tract is the site of large number of tumors of considerable diversity, some very common and some extremely uncommon. The embryology of the female genital tract is relevant to the histogenesis of various tumors arising in this region. This study is conducted to analyze the changing trends of female genital tract tumors in Government Medical College & Rajindra hospital, Patiala over a period of decade and compare it with national/international data.
Methods: This study was carried out on total 400 cases of female genital tract tumors, out of which, 200 consecutive cases of female genital tract tumors were from 2015 and results were compared with data taken from exactly similar study done in the department almost a decade ago to see emerging trends in frequency rates of tumors by the histological type within the site of origin. The tumors were classified according to WHO classification.
Results: A total of 400 cases were studied (biopsies & hysterectomy specimens) and histopathological results were analyzed. Out of 200 cases from 2015, 42 were malignant and 158 were benign. This was in comparison to 28 malignant tumors and 172 benign, out of 200 cases from 2005. Squamous cell carcinoma of cervix was most common invasive malignancy followed by ovarian carcinoma in both the groups. The major burden of benign disease was contributed by uterine lesion, leiomyoma in both the groups.
Conclusion: There has been increase in frequency rate of malignancy in female genital tract tumors in local region. Cervical carcinoma was the commonest female genital tract malignancy followed by ovarian cancer and endometrial cancer.
Keywords: Benign, Female genital tract, Malignant, Tumors.
References
1. Graha W, Berer M, Price J, et al. Raising awareness about reproductive morbidity. Ann Trop Med Parasitol 1992; 86 (suppl 1): 11-18.
2. Ejeckam GC, Abdullah F, EJ Sakka M, Dauleh W, Haseeb F. Gynaecological malignancies in Qatar. East Aft Med J 1994; 71 (12): 777.
3. Gershenson D, Luna G, Malpica A, Kackar U, Whitaker L, Johnson E, Mitchell M. Ovarian intra epithelial neop-lasia. Gynaecological cancer prevention in obstetrics and gynaecology clinics of north America 1996;23(2) : 475.
4. Nwosu SO, Anya SE. Malignancies of the female genital tract at the University of Port Harcourt Teaching Hospital : A ten year review1990-1999. Niger Postgrad Med J 2004; 11: 107-109.
5. Watt WF, Kimbrough RA. Hysterectomy analysis of 1000 consective operations. ObstetGynecol 1956; 7(5): 483-493.
6. Rajshree, Rushed, Mahantappa S, Pattankar VA. A clinicopathologic study of ovarian tumors. Indian J Pathol Micribiol 1997;11(2):239.
7. Naik VS, Rege JD, Jashani KD. Pathology of genital tract in postmenopausal blee-ding. Bombay Hosp J 2005; 47(3): 10-14.
8. Dalsaniya M, Chosi TS, Shrivastav A, Agnihotri AS. Retrospective and prospective histopathological study of tumors and tumor like lesions of femalegenital tract. Int J Med Sci Public Health 2015;4:1602-1604.
9. Dhakal HP, Pradhan M. Histological patterns of gynaecological cancers. J Nepal Med Assoc.2009; 5(2):93-96.
10. The Global Burden of Disease: 2004 Update. Geneva: World Health Organization;2008.
11. Arya A, Narula R, Singh S, Narula K. Benign and malignant tumors of cervix: 10 years study. Int J Med Health Sci.April 2015, 4;186-189.
12. Kamal F, Farrukh R, Khalid AW,Ghazal S, Naheed F, Afsar A. Pattern and frequency of various Uterine Tumors: A retrospective study over a period of 26 months. Biomedica 2003; 19: 36-39.
13. Nasreen F. Pattern of gynaecological malignancies in tertiary Hospital. J Post Grad Med Inst 2002;16(2): 215-220.
14. Kyari O, Ngadda H, Mairiga A. Malignant tumors of the female genital tract in North- Eastern Nigeria. East Afr Med J. 2004;81: 42-45.
15. Franco EL, Franco ED, Ferenczy A. Cervical Cancer: epidemiology, prevention and the role of human papilloma virus infection. Canadian Med Ass J.2001;164:1017-1025.
16. VijenderJeph, Adreena, Prem K Garg, KiraMahabole. Incidence of different malignancies in female genital tract study in 504 women in rural population. International Journal of Contemporary Medical Research. 2017,4(1):284-286.
17. Nkyekyer K. Pattern of gynaecological cancers in Ghana. East Afr Med J2000; 77:534-538.
18. Mohammed A, Ahmed SA, Oluwole OP, Avidine S. Malignant tumors of the female genital tract in Zaria: Analysis of 513 cases. Ann Afr Med.2006;5:93-96.