Title: Hypothyroidism Presenting As Sever Icthyosis and Acanthosis Nigricans
Authors: Dr Gopinath Dubey, Dr Rajiv Kumar Jha, Dr Syed Yousuf Faisal, Dr Sanjeev Kumar, Dr Pankaj Kumar, Dr Prof. B.K.Singh
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.103
Abstract
Background
Hypothyroidism is a common condition with various cause but autoimmune disease and thyroid failure following 131I or surgical treatment of thyrotoxicosis account for over 90% of cases, except in areas where iodine deficiency is endemic.
Thyroid disorders are known to cause a wide range of skin manifestations. Both hypothyroid-dism and hyperthyroidism are known to cause skin changes. Hypothyroidism causes changes in the skin, hair and nails..Many skin disorders like vitiligo, melasma, alopecia areata, xanthelasma palpebrarum, are found to be associated with hypothyroidism. Hypothyroidism is generally associated with thick, dry, cold and pale skin. Thyroid hormones have been shown to be necessary for the initiation and maintenance of hair growth and normal secretion of sebum. The dryness may be so severe that it may resembles an acquired ichthyosis. The most classical cutaneous finding of hypothyroidism is generalized myxedema, where the skin typically appears doughy, swollen, and waxy to touch. Hair of the scalp and body is classically dry, coarse, and brittl. The rate of nail growth is slowed, and nails become brittle.
