Title: Propofol – A Gallery of Different Formulations and Methods to Alleviate Pain on Injection
Author: Vaijayanti Nitin Gadre
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.81
Abstract
Propofol is a popular intravenous (IV) anaesthetic agent both for induction and maintenance. The initial formulations were potent lipid emulsions; efforts to overcome their drawbacks have altered propofol preparation over the decades. Propofol soybean emulsion has been largely acceptable because it is composed of substances endogenous to the body. Pain on injection, allergic reactions, contamination and hyperlipidaemia are the risk factors that occur frequently. Pain on injection is still an unsolved clinical problem during anaesthesia. Various pre-treatment and induction techniques that have been investigated to minimize the incidence of pain have been discussed here and will find the interest of the readers.
Keywords-Propofol, IV Injection, Pain on Injection.
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