Title: Utility of serum ADA estimation in the diagnosis of extrapulmonary tuberculosis
Authors: Prashant Chikkahonnaiah, Surabhi Jaggi, Bela Goyal, Kranti Garg, Seema Gupta, Shivani Jaswal, Kamaljeet Kaur
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.52
Abstract
Background: Adenosine deaminase (ADA) has largely been studied in body fluids for the diagnosis of extra pulmonary tuberculosis (EPTB). Serum ADA has been used as non-invasive assay for Pulmonary TB. The aim of the present study was to test the utility of serum ADA for the diagnosis of EPTB.
Methods: A retrospective analysis of serum ADA values from 122 patients was carried out. The patients were divided into three groups based on their diagnosis i.e. Group A: pulmonary TB patients, group B: Extra pulmonary TB patients and Group C: patients with other respiratory illnesses. Nonparametric tests were performed to compare the groups. Receiver operating curve was plotted to determine the cut-off for knowing the sensitivity and specificity of serum ADA.
Results: The mean serum ADA levels in patients of TB showed significantly higher values than disease controls (other respiratory illnesses). Although, the levels of mean ADA were higher in group B as compared to group A, it was not statistically significant. ROC showed sensitivities of 73.7% and 89.5% for group A and group B respectively at the cut-off of 17.5 and a high AUC of 0.814 and 0.945 for group A and group B respectively when compared to disease controls (group C).
Conclusions: Serum ADA has a potential to be used as surrogate marker for the diagnosis of sputum smear negative and extra pulmonary TB.
Keywords- Serum Adenosine deaminase, Pulmonary tuberculosis, Extra pulmonary tuberculosis.
