Title: A Comparative Study of ‘Sterile Water’ Versus ‘Glycine (1.5%)’ As Irrigation Fluid in Transurethral Resection of Prostate
Authors: Dr Kshitija Kulshreshtha, Dr Ranjeeta Tambey, Dr Naresh G. Tirpude
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.40
Abstract
Aims and Objectives: The present research study was carried out with an objective to study and compare the effects of Sterile Water versus Glycine (1.5%) as an irrigation fluid in surgery of ‘Trans-Urethral Resection of Prostate (TURP).
Methods: This was a prospective randomized double blind study. A total of 60 patients of (Age: 50-80 years) ASA grade I and II with Benign Prostatic Hyperplasia posted for trans-urethral resection of prostate were randomly allocated in two equal groups as Group W- Sterile Water group and Group G- Glycine1.5% group. The observations in relation to intra-operative haemo-dynamics, haemoglobin, blood urea, serum creatinine and serum electrolyte changes were noted and analyzed.
Results: Statistically there were similar changes in heart rate, systolic and diastolic blood pressures during the procedure in both the groups. Immediately after surgery and after 24 hrs, the comparable changes were seen in both the groups in relation to haemoglobin, blood urea and serum creatinine levels. Post-operative serum sodium concentration was decreased and serum potassium concentration was increased significantly in both groups. These changes in serum sodium & potassium were more so in Group W as compared to in Group G; but the difference in two groups was statistically insignificant. Incidence of perioperative complications was comparable amongst the groups.
Conclusion: As compared to Glycine (1.5%), Sterile Water was found to be safe and inexpensive irrigation fluid for ‘Trans-Urethral Resection of Prostate’ (TURP). In relation to safety profile, we did not find any difference between two irrigation fluids. As our sample size of study was small, needs further similar studies on large sample size to confirm the observations of present study.
Keywords: Irrigation fluids: Sterile water Vs. Glycine, Trans-Urethral Resection of Prostate (TURP), Benign Prostatic Hyperplasia, TURP syndrome.
