Abstract
A 54 years old male came with the complaints of raised multiple maculopapular lesions involving the forehead and lateral side of the nose. Skin biopsy showed thinning of epidermis and diffuse monomorphic population of infiltrate involving the dermis and subcutis with round nuclei, high NC ratio and scanty cytoplasm. Complete Haemogram showed low haemoglobin (4.3g/dl), leukocytosis (total count: 43,400/microliter) and marked thrombocytopenia (platelets: 36,000/microliter). Peripheral blood picture revealed acute leukemic picture with 45% myeloblasts and 46% of monocytes and its precursors. It was confirmed as Leukemia cutis with acute myelomonocytic leukemia by further bone marrow aspiration study and immunohistochemistry.
Keywords: Leukemia cutis, bone marrow aspiration, Immunohistochemistry.
References
1. Shino Bay Aguilera, do; Matthew Zarraga, DO; Less Rosen, MD, Leukemia Cutis in a Patient with Acute Myelogenous Leukemia: A case Report and Review of the Literature. Continuing Medical Education. 2010; 85: 31-36
2. Cho-Vega JH, Medeiros LJ, Prieto VG, et al. Leukemia cutis. Am J ClinPathol. 2008; 129: 130-142.
3. Su WP, Buechner SA, Li CY. Clinico-pathologic correlations in leukemia cutis. J Am AcadDermatol. 1984; 11: 121-128.
4. Smoller B. Other lymphoproliferative and myeloproliferative diseases. In: Bolognia JL, Jorizzo JL, Rapini RP, eds. Dermatology. Philadelphia, PA: Mosby; 2003:1943-1952.
5. Brunning RD, Matutes E, Harris NL, et al. Acute myeloid leukemia: introduction. In: Jaffe ES, Harris NL, Stein H, et al, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumoursof Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001:77-80.
6. Shaikh BS, Frantz E, Looking bill DP. Histologically proven leukemia cutis carries a poor prognosis in acute nonlymphocytic leukemia. Cutis. 1987; 39: 57-60.
7. Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002; 100: 2292-2302.
8. Millard TP, Aitchison R, Wilkinson JD. Aleukemic leukemia cutis presenting as a benign appearing eruption. ClinExp Dermatol. 28:148-50,2003.
Corresponding Author
Dr P.Kalaivani M.D.
S1, Thanya Regency, 11/61 Ganesh Nagar Main Road, Selaiyur, East Tambaram, Chennai 600 073
Tamilnadu, India, Mobile - 9843575500
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