Abstract
Background: - Placenta is a vital organ for foetal development, derived from both foetal and maternal tissues and it reflect the status of maternal hypertension.
Aim: The aim of this original research article is to compare the microscopic anatomy of placenta from hypertension associated pregnancies and normal pregnancies.
Method: This study was done in Rama Medical College Kanpur. Placentas from 102 cases of PIH and 100 cases of normotensive pregnant women collected and histological sections studied.
Result: Microscopic study revealed that compare to normotensive women’s histological pattern of placenta in PIH women’s have higher fibrin deposition, calcification, infarction and chorioamnionitis.
Conclusion: Hypertension during the pregnancy lead to pathological changes in placenta.
Keywords: PIH, Preeclampsia, Eclampsia, Placenta, Pregnancy, Hypertension, fibrin deposition, calcification, infarction and chorioamnionitis.
References
1. 1. Ness RB, Roberts JM. Epidemiology of Hypertension. In: LindheimerMD, RobertsJM, Cunningham FG, eds. Chesley’s Hypertensive Disor-ders in Pregnancy. 2nd ed. Stamford, CT: Appleton & Lange; 1999:43–65 (3rd edition revision in press, May 2009, Elsevier).
2. Villar J., Say L., Gulmezoglu A.M., et al. Pre-eclampsia Eclampsia: a Health Problem for 2000 years. In: Critchly H, MacLeanA,PostonL, WalkerJ, eds. Pre-eclampsia. London, England: RCOG Press 2003:189–207.
3. Susan J Fisher. The placental problem: Linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia. Reproductive Biology and Endocrinology 2004; 2:53.
4. Estellés Amparo et al. Abnormal Expression of Type 1 Plasminogen Activator Inhibitor and Tissue Factor in Severe Preeclampsia. Journal of Thrombosis and Haemostasis 1998: 79/3 (Mar) pp.456-690
5. Kanfer A et al. Increased placental antifibrinolytic potential and fibrin deposits in pregnancy-induced hyperten-sion and preeclampsia. Journal of Technical Methods and Pathology 1996, 74 (1):253-258.
6. McKenna D, Tharmaratnam S,Mahsud S, Dornan J. Ultrasonic evidence of placental calcification at 36 weeks’ gestation: maternal and fetal outcomes. Acta Obstet Gynecol Scand 2005;84:7-10
7. Hills D, Irwin GA, Tuck S, Baim R. Distribution of placental grade in high-risk gravidas. AJR Am J Roentgenol 1984; 143:1011-1013
8. Baeza Valenzuela A, Garc´ıa M´endez A. Premature aging of the placenta. Ultrasonic diagnosis. Ginecol Obstet Mex 1995; 63:287-292
9. Brosens I and Renaer M. On the pathogenesis of placental infarcts in pre‐eclampsia. BJOG 1972; 79:794-799
10. Martius, J. & Eschenbach, D.A. The role of bacterial vaginosis as a cause of amniotic fluid infection, chorioamnionitis and prematurity. Arch Gynecol Obstet 1990; 247: 1. doi:10.1007/BF02390649.
Corresponding Author
Dr Rakesh Kumar Shukla
Ph.D Scholar, Department of Anatomy
Rama Medical College, Kanpur, UP, INDIA
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v5i2.114
