Abstract
Back Ground: Acute coronary syndrome (ACS) is still the commonest cause of morbidity and mortality in the cardiovascular disease (CVD) entity worldwide. Studies have shown the effect of thyroid hormones on morbidity and mortality from cardio-vascular events. The sick euthyroid state (SES) has been well associated in ACS affecting the prognosis.
Aim & Objectives: To study the prevalence of SES in patients with ACS, the thyroid profile in ACS and the outcome among the SES patients with ACS. Also to study the distribution of SES according to multiple variables in patients with ACS.
Materials and Methods: The one year study is carried out in our hospital and designed as cross sectional study. Study group included 155 patients diagnosed to have ACS. History, clinical examination and risk stratification is done. Blood samples, thyroid profile, serial ECGs and Echocardiography are done for all patients. Data is analyzed for prevalence by percentage and Chi-square tests used for P-values and significant correlations.
Results: Prevalence of SES in ACS is 25.5%.Statistically Significant P-values for High BMI, CRP positivity, worst outcome in SES group of ACS were observed, correlating well with several studies. Low T3 values and Increased rT3 value (sick euthyroid state) is correlating with the worst outcome in ACS.
Conclusion: Prevalence of sick euthyroid state (SES) is very common in patients with ACS. Almost one quarter of ACS patients had SES. SES significantly associated with high BMI, CRP positivity is associated with worst outcome. So, Sick euthyroid state is a strong prognostic indicator in ACS. The T3 and rT3 levels well correlated with the outcome.
Keywords: Sick euthyroid state, CRP-c reactive protein, Acute coronary syndrome.
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Corresponding Author
Santhi Thoppappatty Sengottaiyan
Associate Professor of Medicine, Govt. Kilpauk Medical College, Chennai-10, India
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.. Tel: 0919444048536
DOI: https://dx.doi.org/10.18535/jmscr/v5i2.108
