Title: Recurrent Malignant Phyllodes Tumour of the Breast with Liposarcomatous Differentiation: A Rare Case Report and Review Of Literature
Authors: Dr M Kumara Raghavendra Varma, Prof. Bhaskaran A, Dr Pavan B K, Dr Asadulla Baig
DOI: https://dx.doi.org/10.18535/jmscr/v5i2.84
Abstract
INTRODUCTION
Phyllodes tumor of the breast usually is a biphasic fibroepithelial neoplasm. Malignant transform-ation is seen in 10 to 20 % of cases and manifests in the form of fibrosarcomatous differentiation and rarely heterologous sarcomatous elements. Liposarcomatous differentiation is a rare entity among phyllodes tumors.
Spindle cell carcinoma is an unusual neoplasm commonly observed in the oral cavity1 and the larynx2. However, on rare occasions it occurs in the breast3, 4. Primary pure breast sarcoma is a rare disease and constitutes 0.2–1.0% of all mammary malignancies5.
Primary pure breast sarcomas or advanced breast sarcomas are rare and mostly secondary to radiotherapy. Latter forms the majority of breast sarcomas. Reported 5-year survival rates for patients with breast sarcoma range from 40 to 91%6, 7, 8
Sarcomatous stromal elements, including angiosarcoma, leiomyosarcoma, and rhabdomy-osarcoma, are infrequent in malignant phyllodes tumors. Liposarcomas usually show stromal components of phyllodes tumors. Liposarcom-atous differentiation is confirmed by noting well differentiated, myxoid, round cell, and pleomorphic liposarcomatous elements. The finding of a malignant heterologous element places the tumor into a malignant category.
