A Study on C Reactive Protein - Morbidity Predictor in Ischaemic Stroke

Title: A Study on C Reactive Protein - Morbidity Predictor in Ischaemic Stroke

Authors: Brinda.J, John Christopher Ponnaiyan, Suresh Kumar, Manivel Ganesan

DOI: https://dx.doi.org/10.18535/jmscr/v5i2.74

Abstract

Background: With an annual incidence of 0.2 to 2.5 per 1000 population, CVA is an important health problem worldwide. Though ischaemic CVA is one of the leading causes for death and disability, parameters for predicting, long term outcome in such patients have not been clearly delineated, especially in the Indian context. Various studies proved that C-reactive protein at admission was found to be a predictor of functional disability in ischaemic CVA. Inflammation regulates the production of the acute phase proteins such as c-reactive protein (CRP), fibrinogen and serum amyloid A. The serum concentration of CRP can increase >1000 fold upon inflammation and with a half life of 19 hrs, CRP is a very stable marker of the inflammatory process. Most recent studies report that CRP is an independent predictor of risk of atherosclerosis, cardiovascular events, atherothrombosis, hypertension and myocardial infarction.

Materials and Methods: The present study is a prospective study and was conducted on 49 patients in the Department of General Medicine, Kanyakumari Government Medical college from January 2016 to January 2016. Various cerebrovascular accident cases admitted in our hospitals were clinically evaluated and diagnosis were confirmed radiologically. All cases were subjected to routine blood investigations along with acute phase proteins (c-reactive protein) on the day of admission and after 4 weeks. In all 49 cases, informed consent obtained from their guardians.

Results: Out of total 49 cases studied, 18 Cases were females & 31 cases were males. All the cases were grouped into 3 categories by Barthels Index accordingly. Patients with high C- reactive protein levels on the day of admission had more severe deficits and poor prognosis after 4 weeks than compared with other patients with normal level on the day of admission and better prognosis.

References

1. Di Napoli M, Di Giantilippa a, sollecito A Bocala V - CRP and outcome after first ever stroke 31(1) 238 - 9 Jan 2001

2. Di Napoli M, Di Gianfillippo G, Bocala V C.Reactive protein after first ever ischaemic stroke Neurology 1999, 52 : A 151 - A 152

3. Muir K.N., Weir CJ Alwan W, squire IB, Lees KR, C.Reactive protein and outcome after ischaemic stroke : Stroke 1999 ; 30 : 981 -985

4. Mahoney FI, Barthel DW, functional evaluation, the Barthel Index Md state Med J 1965 : 14 : 61 - 65

5. Grace A.J. Infection, Inflammation and cerebro vascular Ischaemic Neurology 1997 : 49 (suppl 4): S 47 - S 51

6. Volanakis JE complement activation by C.Reactive protein complexes.

7. Plasma concentration of C.Reactive protein and risk of Ischaemic stroke and Transient Ischaemic attach. The Framingham study Natalia S.Rost, Philip A Wolf, Carlas S.kase stroke 2001 : 32 : 2575 - 2579.

8. Morbidity predictors in ischemic stroke J N Panicker, M.Thomas, K.Parithran D.Nair, P.S.Sarma Neurology India Vol 51 No 1 Jan - mar 2003 pp 49 -51

9. Wide Range C Reactive Protein efficacy in acute ischaemic stroke patients S.Shenhar - Tsartaty, E.Ben Assayag, I.Bova. Acta Neurol Scand 2006 : 114 : 29 - 32.

10. CHAMORRO A. Role of inflammation in stroke and athero thrombosis.Cerebro vascular diseases 2004 : 17 (Suppl 3) 1-5

11. Winbeck K, Poppert H, Etgen T, Cornard B, Sander B, Prognostic relevance of early serial C Reactive protein measurement after first ischaemic stroke 2002 ; 33 ; 2459-64.

12. CRP in cerebro vascular events, Carnova CR, Courtin C Rein hart W.H. Atherosc-lerosis 1999 Nov 1 : 147(1) : 49 -53.

13. Complement C3 and C.Reactive protein are elevated in South Asians Independent of a family History of stroke. Somane R, Grant PJ, Kain K stroke 2006 Jun 29.

14. Zwaka T, Homback V, Torzewski J C.Reactive protein mediated low density lipo protein up take by macrophages. Implications for atherosclerosis circulation 2001 : 103 : 1194- 1197.

15. C Reactive Protein, carotid intima media thickness and incidence of ischaemic stroke in the elderly the cardiovascular Healthy study circulation 2003 Jul 15: 108(2) 166-70.

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