Abstract
Aim: To measure and compare the LDH levels in serum and saliva in tobacco users and potentially malignant disorders.
Materials And Methods: Thirty subjects were recruited for this study and divided into three groups, 10 subjects with tobacco habits, 10 subjects with potentially malignant disorders and 10 healthy controls. Venous blood and unstimulated whole saliva measuring 1 ml was collected from each of these were evaluated for LDH levels using the standard kit method. The data obtained were subjected to statistical analysis using the spss software version 17.
Results: LDH activity increased in serum as well as saliva in tobacco users and potentially malignant disorders in comparison to normal control.
Conclusion: Salivary LDH estimation can prove to be a valuable substitute to serum LDH as a biochemical marker, as it is a simple, non invasive and tool for diagnosis and monitoring of oral precancer and cancer.
Keywords: Lactate dehydrogenase, tobacco, potentially malignant disorders, serum, saliva.
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DOI: https://dx.doi.org/10.18535/jmscr/v5i2.72
