Abstract
Hemophagocytic syndrome is a rare and potentially fatal disorder characterised by pathological immune activation associated with primary familial disorder, genetic mutation or occurring as a sporadic condition. The later can be secondary to infections, malignancies or autoimmune diseases. Malignancy associated HLH is commonly seen in haematological malignancies and rarely with solid organ tumours.
We report a case of "Adenocarcinoma of colon" presenting as Hemophagocytic syndrome, to our knowledge, this is the first case report of HLH secondary to Carcinoma colon, a rare presentation of solid organ malignancy.
Keywords: Hemophagocytosis, Carcinoma colon, Malignancy.
References
1. Farquhar jw, claireux AE. Familial hemophagocytic reticulosis. Archives of disease in children 1952:27:519-523.
2. Gurgey A et al. primary HLH in Turkish children. Paediatric hematol oncol 2003: 20: 360-371.
3. Step SE.Dufoureq-lagelouse et.al. Perforin gene defects in familial HLH. Science 1999:286:1957-59.
4. Huck K. Foyen O. et.al. Girls homozygous for kinase mutation that leads to protein deficiency develop fatal HLH. J.clin. invest. 2009: 119:1350-5.
5. Alison M et.al. “How I treat HLH in adult patients ‘published online march 10 2015.
6. Y.T. Bryce son et.al. A prospective evaluation of degranulation assays in rapid diagnosis of familial hemophagocytic syndromes. Blood .119:2754-2763.2012.
7. Weitzman.”Approach to hemophagocytic syndrome” haematology: the education programme of American society of haematology, Vol. 2011, 178-183.2011.
8. K. Koizumi et.al. “The HLH syndrome in Prostate cancer: the journal of urology Vol.168. 1101-2 Sept. 2002.
9. Cristnia Oliveria et.al. Case reports in haematology. Hindwai publishing corporation volume 2014, article ID 958425.
10. Hunter J-I et.al.HLH-2004. Diagnostic and therapeutic guidelines for HLH: Paediatric Blood Cancer 2007:48:124-131.
11. M.B. Jordan et.al. “How I treat HLH” Blood vol.118: 4041-4052. 2011.
12. Hunter J Samuelson et.al. Treatment of hemophagocytic lymphohistiocytosis. Blood 2002:100:2367-2373.
Corresponding Author
Dr Murtaza Ali
D2 Ward, 2nd Floor, Deptt. of Medicine
All India Institute of Medical Sciences (AIIMS), New Delhi-29
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v5i2.56
