Abstract

Introduction: Navi Mumbai is an endemic area for Malaria which is one of the most common parasitic infectionsand major public health problem in India.The clinical features of malaria in children are nonspecific and vary significantly. The aim of our study was to find out the spectrum of clinical manifestations, infecting species, age distribution and mortality in admitted patients of malaria in our hospital andto compare the clinical profile with severity of P.vivax and P. falciparum malaria in pediatrics age group in a tertiary care hospital.

Methods: This was a one year retrospective and one year prospective study.Children below 14 years of age who were smear positive for plasmodium species or malarial antigen positive were included in the study. Statistical analysis was done using chi square test for comparing proportions. P value < 0.05 was considered significant.

Results: The data was analyzed by the appropriate statistical methodsand laboratory parameters were recorded carefully . A total of 106 patients were studied  of 67 patients of Plasmodium vivax, 22 patients of Plasmodium falciparum and 02 patients of Mixed malaria. Complications observed were severe anemia, thrombocytopenia, renal dysfunction, jaundice, metabolic acidosis and acute respiratory distress syndrome (ARDS). Thrombocytopenia and severe anaemia were the most frequent complications in the severe cases. 05 of106 patients (4.7%) were expired. 2/5 patients who expired had four or more organ dysfunction.

Conclusion: Severe Anemia and Thrombocytopenia has the significant correlation with mortality. Other significant factors contributing to death were jaundice and renal failure. Severe form of malaria is seen in vivax malaria and the age group affected by vivax also is younger.Plasmodiumvivax infection is common infecting species. Multi organ involvement and severe manifestations commonly observed in vivax  infection.

Key words: Severe Malaria, Vivax, Falciparum, Mortality.

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