Title: Serum Periostin Level in Children with Bronchial Asthma: A Comparative Study
Authors: Marwa Elhady, Mohamed Abdelmalik, Ibrahim Abu Farag, Shahinaz Elattar, Ismail Alwakil
DOI: https://dx.doi.org/10.18535/jmscr/v5i1.55
Abstract
Background: Assessment of pulmonary function is important for diagnosis and monitoring of bronchial asthma. The role of biomarkers in assessment of bronchial asthma is an area of increasing interest. However, debate continues on the optimal parameters to be included and the role biomarkers play in the clinical assessment of asthma.
Aim: To evaluate the role of serum periostin level for assessment of children with bronchial asthma.
Method: this comparative study included 60 asthmatics and 30 healthy children as a control group; age and sex were matched. They were classified according to severity and level of asthma control. We investigated the correlation between serum periostin level, spirometer parameters and their relation to severity of bronchial asthma and the level of control in children. Regression analysis was done to determine risk factors for impaired pulmonary function in children with asthma.
Results: serum periostin was significantly higher in asthmatics than controls and in patients with uncontrolled compared to controlled asthma. It was significantly higher in those with severe and moderate asthma than those with mild asthma. Significant negative correlation between serum periostin level and pulmonary function parameters were detected. A logistic regression analysis showed that serum periostin level was predictor of impaired forced expiratory volume 1 (FEV1) in asthmatic children with 72.22% sensitivity and 88.1% specificity.
Conclusion: Serum periostin is a promising biomarker of treatment response and disease progression that could be used for optimization of drug doses and prediction of impaired pulmonary function in children with bronchial asthma.
Keywords- periostin, children, spirometer, bronchial asthma.
