Abstract
AIMS: Alpha 2 agonist are popularly used as adjunct in general anaesthesia. A study was carried out to investigate the ability of intravenous Dexmedetomidine vs Clonidine to maintain hemodynamic response in spine surgery.
METHODS: 60 patients scheduled for spine surgery were randomized in two groups 0f 30 each. Group D-received 0.5µg/kg Dexmedetomidine IV diluted in 10ml of normal saline given slowly over 10 min. Group C –received 0.5µg/kg Clonidine IV diluted in 10 ml of normal saline given slowly over 10 min.
Hemodynamic parameter were recorded after 10 min of giving study drug. Observations of parameters were maintained at 2,5,10 min and carried out till 110 min of duration.
RESULTS: The demographic profile was comparable. The pressor response to laryngoscopy, intubation, surgery and extubation were effectively decreased with dexmedetomidine and was highly significant on comparison with clonidine (P<0.0001).
CONCLUSION: Dexmedetomidine is an excellent drug to maintain hemodynamic response to intubation as compared to clonidine in spine surgery ,and better in achieving adequate analgesia and anaesthesia perioperatively.
KEYWORDS: Spine surgery, Dexmedetomidine, Clonidine, General anaesthesia.
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Corresponding Author
Dr Rashmi Bengali
C-19 Town Centre Cidco Aurangabad
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile no.9822441318
Dr Rohini Pawar
Plot no. 191/6 Sector C Shiveshwar Colony, Opp Sboa School Jalgaon Road Aurangabad
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile no.9823017640
DOI: https://dx.doi.org/10.18535/jmscr/v5i1.24
