Abstract
Introduction: Pulmonary arterial hypertension (PAH) is a type of high pressure that occurs in the right side of the heart and in the arteries that supply blood to the lungs (pulmonary arteries). It has an estimated prevalence of 15-50 cases per million. Idiopathic PAH has an annual incidence of 1-2cases per million people in the US and Europe and is 2-4 times more common in women than in men. The mean age at diagnosis is around 45 years. It is unfortunately most frequently diagnosed when patients have reached an advanced stage of the disease (WHO functional class III and IV). A combination of lifestyle changes, medicines and surgeries may alter the progression of the disease but unfortunately, treatment cannot reverse the symptoms and damage caused by PAH.
Aims and Objectives: To study the clinical features of PAH and its echocardiographic changes and also to evaluate the relationship between echocardiographic findings and clinical features in patients with PAH.
Methods: Prospective observational study of 50 patients conducted at MGM Medical College and Hospital, Navi Mumbai between November 2013 to October 2015 for a period of almost two years.
Results and Conclusion: The study conducted to evaluate clinical and echocardiographic correlation in patients of PAH showed that the incidence of PAH is higher in females. It is more common in the higher age group. Dyspnoea is the most common presenting symptom. Maximum patients had TR jet changes followed by RA/RV (Right Atrium/Right Ventricle) changes in echocardiography. Maximum patients had moderate PAH in accordance with echocardiographic changes. Statistically significant co-relation was found between ABG and echocardiographic changes in the study.
Keywords: Pulmonary arterial hypertension, Dyspnoea, Elevated JVP, LoudP2, TR jet changes, RA/RV changes, ABG.
References
1. Simonneau G, Robbins I, Beghetti M, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 2009;54:S43-S54.
2. Badesch DB, Raskob GE, Elliott CG, et al. Pulmonary arterial hypertension: baseline characteristics from the REVEAL Registry. Chest 2010;137:376–87
3. Humbert M, Sitbon O, Chaouat A, et al. Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med 2006;173:1023–30.
4. David B. Badesch, Gary E. RaskobGreg Elliott et al. Pulmonary Arterial Hypertension: Baseline Characteristics From the REVEAL Registry. Chest. 2010;137(2):376-387. [13].
5. Raymond L. Benza, Dave P. Miller et al. Predicting Survival in Pulmonary Arterial Hypertension : Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL). Circulation. 2010; 122: 164-172.
6. Charles D. Burger, Aimee J. Foreman et al. Comparison of Body Habitus in Patients With Pulmonary Arterial Hypertension Enrolled in the Registry to Evaluate Early and Long-term PAH Disease Management With Normative Values From the National Health and Nutrition Examination Survey. Mayo Clin Proc. Feb 2011. 86(2): 105-112.
7. Asif Hasan, Muhammad Uwais Ashraf, Sandeep Kumar [International Journal of Enhanced Research in Medicines & Dental Care, ISSN:2349-1590 Vol.1 Issue 2, April-2014, pp:(14-2)]
8. Rich S, Dantzker DR, Ayres SM, Bergofsky EH et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med. 1987.
9. Miyamoto S.,M Nagaya N., Satoh T.; Clinical correlates and prognostic significance of six- minute walk test in patients with primary pulmonary hypertension: Comparison with cardiopulmonary exercise testing .Am J Respir Crit Care Med. 161 2000:487-492.
10. Haeck ML, Scherptong RW, Ajmone Marsan N, Holman ER, Schalij MJ, Bax JJ, et al. Prognostic value of right ventricular longitudinal peak systolic Journal of the American Society of Echocardiography Volume 26 Number 1 Bossone et al 11 strain in patients with pulmonary hypertension. Circ Cardiovasc Imaging 2012;5:628-636.
11. Sitbon O., Lascoux-Combe C., Delfraissy J.-F.; Prevalence of HIV –related pulmonary arterial hypertension in the current antiretroviral therapy era.Am J Respir Crit Care Med. 177 2008:108-113.
12. Marius M. Hoeper, MD, Harm Jan Bogaard, MD et al. Definitions and Diagnosis of Pulmonary Hyperten-sion.Vol.62, No.25, Suppl. D, 2013, ISSN 0735-1097, Journal of American College of Cardiology.
DOI: https://dx.doi.org/10.18535/jmscr/v5i1.23
