Title: Gastroprotective Effects of Gloriosa Superba Tubers against HCL/Ethanol Induced Gastric Mucosal Injury in Rats
Auhors: Siddhi Ashokkumar Mehta Falguni, Mrs. Rachana D. Sarawade, Ayyub Shaikh, Vishakha Trivedi, Freny Menezes
DOI: http://dx.doi.org/10.18535/jmscr/v3i8.43
DIDS : 08.2015-XXXXXXX
The purpose of this study was to evaluate gastroprotective activity of Gloriosa superba tuber extract (GSTE) on HCL/Ethanol induced gastric ulcers. Gloriosa superba plant is used for treatment of various diseases. Disease control group exhibited severe mucosal injury as compared to standard group (Omeprazole) and test group (GSTE) which showed protection towards gastric mucosal injury. Gastric wall mucus was significantly replenished by the pre treatment of test group and standard group which was reduced by HCL/Ethanol. Also antioxidants enzymes (SOD and LPO) were also brought back to normal level up to certain extent by test drug and Omeprazole. Keywords: Gastroprotective, Gloriosa superba, SOD, LPO. 1. Walaa Najm Abood, Mahmood A. Abdulla and Salmah Ismail; Involvement of Inflammatory mediators in gastroprotective action of Phaleria macrocarpa against Ethanol-induced gastric ulcers; World applied science journal 30; 344-350,2014. 2. Manal Mohamed Elhassan Taha, Muhammad Saleh Salga, Hapipah Mohd Ali, Mahmood Ameen Abdulla, Siddiq Ibrahim Abdelwahab, A.Hamid A. Hadi; Gastroprotective activities of Turnera diffusa wild.ex schult; revised : role of arbutin; journal of Ethanopharmaology; 141(2012) 273-281. 3. M.Dorababu, M.C.Joshi, Bhawani G., M.Mohankumar, Aditi Chaturvedi and R.K.Goel; Effect of Aqueous extract of neem (Azadiracta Indica) leaves on offensive and defensive gastric mucosal factors in rats; Indian J Physiol Pharmacol 2006; 50(3); 241-249. 4. KP.Latha, H.Kirana and HN.Girish; Anti-Implantation activity of the hydro alcoholic tuber extract of Gloriosa superba Linn in female Albino rats; IJAPBC-vol.2 (3); jul-sep, 2013. 5. Saradha devi Muthukrishnan, Annapooorani Subramaniyam; International journal of pharmaceutical research development (IJPRD); 2013; vol 5(06) Aug-2013(102-108). 6. CK Kokate, Practical Pharmacognosy; 4th edition; Vallabh Prakashan; New Delhi. 7. GE Trease, WC Evans; Pharmacognosy, 15th edition; WB Saunders Publishers. 8. Ahmed S. AlRashidi, Suzy M.Salama, Salim S. Alkiyumi, Mahmood A Abdulla, A. Hamid A. Hadi, Siddig I.Abdelwahab, Manal M Taha, Jamal Hussiani, and Nur Asykin; Mechanism of gastroprotective effect of ethanolic leaf extract of Jasminium sambac against Hcl/Ethanol induced gastric mucosal imjury in rats; Hindawi Publishing Corporation, Volume 2012, Article ID 786426. 9. N.L. Dashputre, N.S. Naikwade; Evaluation of Anti-ulcer activity of methanolic extract of Abutilon indicum Linn leaves in experimental rats; International journal of pharmaceutical sciences and drug research 2011; 3(2); 97-100. 10. J.Mojzis, R.Hegedusova, L.Mirossay; Role of mucus in ischemia/Reperfusion-induced gastric mucosal injury in rats; Physiol.Res.49:441-446, 2000. 11. Mahmood Ameen Abdulla, Khaled Abdl-Aziz Ahmed, Fouad Hussain Al-Bayaty and Yaghma Masood; Gastroprotective effect of Phyllanthus niruri leaf extract against ethanol- induced gastric mucosal injury in rats; African journal of pharmacy and pharmacology; vol 4(5); pp.226-230; may 2010. 12. K.T. Mani, Senthnil Kumar 1, Zothan Puia1, Samir K. Samanta1, Rajiv Barik 1, Arnab Dutta 1, Bapi Gorain 1, Dilip K. Roy1, Dipan Adhikari 1, Sanmoy Karmakar1, Tuhinadri Sen; The gastroprotective role of Acanthus ilicifolius- A study to unravel the underlying mechanism of Anti-ulcer Activity; sci Pharm. 2012; 80: 701-717.Abstract
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