Abstract
Blood transfusion is one of the commonest accompaniments of surgical practice. With a growing incidence of major polytrauma by vehicular accidents, bomb blasts and fires, awareness of the basic concepts underlying massive blood transfusion practice with special reference to the complications is essential. The paper outlines the pathophysiologic mechanisms underlying the various complications of massive blood transfusion.
Key Words: Massive blood transfusion complications.
References
1. Donaldson MDJ, Seaman MJ, Park GR. Massive Blood Transfusion. Br J Anaesth 1992; 69: 621-30.
2. Bux J. Transfusion related acute lung injury (TRALI): a serious adverse event of blood transfusion. Vox Sang. 2005; 89:1-10.
3. Kopko PM, Holland PV. Mechanisms of severe transfusion reactions. TransfusClin Biol. 2001;8: 278-81.
4. Kirkley SA. Proposed mechanism of transfusion induced immunomodulation. ClinDiagn Lab Immunol. 1999; 6: 652-57.
5. Sihler KC, Napolitano LM. Complications of massive transfusion. Chest. 2010; 137: 209-220.
6. Henderickson JE, Hillyer CD. Noninfectious srious hazards of transfusion. Anaesth Analg. 2009; 108: 759-769.
7. Miller RD. Massive blood transfusion: The impact of Vietnam military data on modern civilian transfusion medicine. Anaesthesiology. 2009; 110: 1412-1416.
8. Teague G, Gaylard D. Transfusion related lung injury. Anaesth Intensive Care. 2005; 33: 124-127.
9. Spinella PC. Warm fresh whole blood transfusion for severe haemorrhage: US military and potential civilian applications. Crit Care Med. 2008; 36 (suppl7): 340-345.
10. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003; 54: 1127-30.
11. Meibner A, Achlenke P. Massive Bleeding and Massive Transfusion. Transfus Med Hemother. 2012; 39: 73-84.
12. Dutton RP. Resuscitative strategies to maintain homeostasis during damage control surgery. Br J Surg. 2012; 99(Suppl1): 21-8.
Corresponding Author
Dr. Ketan Vagholkar
Annapurna Niwas, 229 Ghantali Road Thane 400602 MS. India
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile: 9821341290
DOI: http://dx.doi.org/10.18535/jmscr/v3i10.58
