Title: Study on Thyroid Dysfunction in Patients Attending Rama Medical Collage Hospital & Research Centre, Kanpur (Uttar Pradesh)- A Hospital Based Study
Authors: Dr Pavan Kumar Sharma, Dr P. B. Jain, Dr P. Anand, Dr I. Chaudhary, Mr S. Sharma
DOI: http://dx.doi.org/10.18535/jmscr/v3i10.10
Thyroid dysfunction is defined as the altered serum thyroid stimulation hormone (TSH) level with normal or altered thyroid hormones (tri-iodothyronine- T3 and thyroxine- T4). Decreased level of circulating blood TSH with increased levels of circulating T3 andT4 is called overt hyperthyroidism whereas decreased level of circulating blood TSH with normal levels of circulating T3 andT4 is called subclinical hyperthyroidism. Increased level of circulating blood TSH with decreased levels of circulating T3 andT4 is called overt hypothyroidism whereas increased level of circulating blood TSH with normal levels of circulating T3 andT4 is called subclinical hypothyroidism. A total 354 subjects were enrolled in this study out of these 265 were female and 89 were male. The subjects were classified according to thyroid status as euthyroidism, overt hyperthyroidism, subclinical hyperthyroidism, overt hypothyroidism and subclinical hypothyroidism by taking reference of thyroid function test. Total hypothyroidism includes overt hypothyroidism plus subclinical hypothyroidism and total hyperthyroidism represents overt hyperthyroidism plus subclinical hyperthyroidism. Overn ight fast venous blood was collected from the subjects attending RMCHRC, Kanpur. Thyroid function test panel (T3, T4 and TSH) were assayed by the Cobas e411 immunoassay analyzer and its test kits. The present study has revealed the prevalence of thyroid dysfunction typically hypothyroidism and subclinical hypothyroidism were higher in this region but the etiology of the disease remains unidentified. Moreover, the disease was preponderant in women and the people of all age-group. Our study was a hospital based study; it may not represent the whole population. But, the study has identified the burden of thyroid dysfunction in this locality and can be used as baseline data for future studies. KEY WORDS: T3, T4and TSH, Euthyroid and Thyroid dysfunction.
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