The Expression of IGF- Binding Protein-related Protein 1 (IGFBP- rP1) In Colorectal Carcinoma (CRC) Among Diabetic and Non-Diabetic Patients

Title: The Expression of IGF- Binding Protein-related Protein 1 (IGFBP- rP1) In Colorectal Carcinoma (CRC) Among Diabetic and Non-Diabetic Patients

Authors: Anani Aila Mat Zin, Sharifah Emilia Tuan Sharifand Nor Hayati Othman

DOI: http://dx.doi.org/10.18535/jmscr/v3i11.25

Abstract

References

Corresponding Author

Abstract

Insulin-like growth factor (IGF)-binding protein-related protein 1 (IGFBP-rP1) is a member of the Insulin Growth Factors (IGF) axis. IGFs plays role in glucose metabolism, promoting cell migration, mitogens, antiapoptotic and cell-survival factor. Type 2 Diabetes Mellitus or hyperinsulinemia state is hypothesized to promote colorectal carcinogenesis directly or indirectly by increasing the insulin-like growth factor-1 (IGFBP-rP1). This study was conducted to determine the expression and the association of IGFBP-rP1 protein in patients with colorectal carcinoma (CRC) with and without Diabetes Mellitus Type 2 (DM2). A total of 111 cases of CRC with or without clinically confirmed DM2 in Hospital Universiti Sains Malaysia Kelantan from year 2000 to 2010 were included. Results showed a significant expression of IGFBP-rP1 among CRC cases with (69%) and without DM2 (42%). Univariate analysis showed significant association of IGFBP-rP1 with DM2 (p<0.05), stage of the tumour (p=0.005) and tumour local invasion (p=0.037). These results were further strengthened using multiple logistic regression analysis. There was an increased expression of IGFBP-rP1 in colorectal cancer patients with diabetes mellitus type II. This study supports theory that chronic hyperinsulinemia indirectly promotes colorectal carcinogenesis via IGFBP-rP1, which might play an important role in the initiation and promotion of the cancer.

Keywords: IGFBP-rP1, Colorectal Carcinoma, Diabetes Mellitus

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