Title: Evaluation of Serum Cystatin-C and Serum Creatinine Levels in Type-2 DM
Authors:Krishan Kant Pandey, Dr Neelimia Singh, Dr Arun Raizada
DOI: http://dx.doi.org/10.18535/jmscr/v3i11.13
Type-2 diabetes has become the most common metabolic disorder in India and is a growing problem with over 40 million diabetic subjects. The “Asian Indian phenotype” is associated with increased insulin resistance, greater abdominal adiposity despite lower body mass index, lower adiponectin and higher high sensitivity C - reactive protein levels and makes Asians more prone to diabetes. Among Indians, the onset of type 2 diabetes occurs at a younger age and hence, they are vulnerable to all the complications of diabetes due to longer duration of the disease. An overnight fasting blood sample was collected from both cases and controls and the samples were centrifuged and separated for the estimations. Estimations of fasting blood glucose, blood urea and serum creatinine were performed using the serum. Estimation of serum cystatin C was done by immunoturbidimetric method. The mean age of cases in this study was 56.16±10.47 with a body mass index of 25.7±4.15. The mean & S.D. of blood urea, serum creatinine & serum cystatin C were 36.88±12.48, 0.98±0.32 & 1.61±0.45 in cases. The study shows significant increase in serum cystatin C levels in diabetic individuals compared to controls. These finding that the measurement of serum cystatin C levels in type-2 DM as a marker of renal impairment. Keywords: Type-2 DM, cyctatin C and marker of renal impairment.
Abstract
