Protective effect of Apple Cider Vinegar on Stress Induced Gastric Ulcer

Title: Protective effect of Apple Cider Vinegar on Stress Induced Gastric Ulcer

Authors: Hader Ibrahim Sakr, Mohamed Mansour Khalifa, Mohamed Al Sayed Saleh, Laila Ahmed Rashed, Akef Abdel Halim Khowiled

DOI: http://dx.doi.org/10.18535/jmscr/v4i1.28

Abstract

References

Corresponding Author

Abstract

A gastric ulcer is a break in the normal gastric mucosa integrity that extends through the muscularis mucosa into the sub-mucosa or deeper. This work aimed to study the effect of chronic administration of vinegar on gastric acid secretion, and if this action has any effect on stress-induced ulcer in male albino rats. Study groups included 24 rats divided into 2 main groups (12 rats/group): pyloric ligation group (A) and water immersion-induced gastric ulceration group (as a form of stress) (B). We evaluated; free and total HCL secretion in group A, ulcer score, ulcer index, percentage ulcer protection, , eNOS enzyme activity, COX-2 enzyme activity, glutathione reductase gene expression, CCK gene expression and proton pump (H⁺/K⁺ ATPase) gene expression in group B. We revealed significant decrease in free and total acidity, ulcer score and index, COX-2 enzyme activity and Proton pump (H⁺/K⁺ ATPase) gene expression among vinegar fed rats compared with the results of the control group. On the other hand there was significant elevation in the percentage ulcer protection, eNOS enzyme activity, glutathione reductase gene expression and CCK gene expression among vinegar fed rats compared to control group. In conclusion, the present study revealed protective effect of vinegar on stress-induced gastric ulceration.

Key words: Gastric ulcer, HCl, H⁺/K⁺ ATPase pump, H₂-receptor blockers, vinegar.

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