Title: Severe Vit B12 Deficiency Presented As Encephalopathy in a 5 Yr Child
Authors: Dr Subhranshu Sekhar Dhal, Dr Sunil Kumar Agarwalla, Dr Tapan Kumar Biswas, Dr Shantanu Kumar Meher
DOI: http://dx.doi.org/10.18535/jmscr/v4i9.06
Vit B12 plays important role in different organ in our body, most importantly haematological system and central as well as peripheral nervous system. So its deficiency in children can cause poor weight gain, developmental regression, mental changes, abnormal movements, encephalopathy or may leads to long-term neurological sequelae. Early diagnosis and prompt treatment can alter the disease process. Here we present a case of severe vit B12 deficiency, who admitted with encephalopathy and successfully treated with a good neurological outcome almost towards normal. Keywords- vit B12 deficiency, encephalopathy, developmental regression. 1. S. P. Stabler, R. H. Allen, D. G. Savage, and J. Lindenbaum, “Clinical spectrum and diagnosis of cobalamin deficiency, ” Blood, vol 76, no. 5, pp. 871–881, 1990. 2. Honzik T, Adamovicova M, Smolka V, Magner M, Hruba E, Zeman J. Clinical presentation and metabolic consequences in 40 breastfed infants with nutritional vitamin B12 deficiency – what have we learned? Eur J Paediatr Neuro. 2010; 14:488–95. [PubMed] 3. Zengin E, Sarper N, Caki Kiliç S. Clinical manifestations of infants with nutritional vitamin B12deficiency due to maternal dietary deficiency. Acta Paediatr. 2009; 98:98–102. [PubMed] 4. Jump up to:a b c McBride, Judy (2 August 2000). "B12 Deficiency May Be More Widespread Than Thought". Agricultural Research Service. United States Dept of Agriculture. Retrieved 2 July 2012. 5. Jump up^ Thomas, Donald (2011-06-22). New Jump Swing Healthy Aging and Athletic Nutrition Program. Xlibris. p. 41. ISBN 978-1-4628-8427-8. 6. Kamei M, Ito Y, Ando N, Awaya T, Yamada T, Nakagawa M. Brain atrophy caused by vitamin B12-deficient anemia in an infant. J Pediatr Hematol Oncol. 2011; 33:556–8. [PubMed] 7. van Loon M, Postels DG, Heikens GT, Molyneux E. Severe pernicious anaemia in an 8-year-old African girl. Ann Trop Paediatr. 2009; 29:231–4. [PubMed 8. Jump up^ Schwartz, William (2012). The 5-minute pediatric consult (6th ed.). Philadelphia: Wolters Kluwer Health/ Lippincott Williams & Wilkins. p. 535. ISBN 9781451116564. 9. Jump up^ Reynolds, E.H. (2014). "The neurology of folic acid deficiency". Handb Clin Neurol. 120: 927–43. doi:10.1016/B978-0-7020-4087-0.00061-9. PMID 24365361. 10. Jump up^ Briani C, Dalla Torre C, Citton V, Manara R, Pompanin S, Binotto G, Adami F (2013)."Cobalamin Deficiency: Clinical Picture and Radiological Findings". Nutrients. 5 (11): 4521–4539. doi:10.3390/nu5114521. ISSN 2072-6643. PMC 3847746 11. Jump up^ DN Amarapurka MD, ND Patel MD (Sept 2004). "Gastric Antral Vascular Ectasia Syndrome". Journal of The Association of Physcians of India. 52: 757. 12. Jump up^ Matsumoto A, Shiga Y, Shimizu H, Kimura I, Hisanaga K (Apr 2009). "[Encephalomyelopathy due to vitamin B12 deficiency with seizures as a predominant symptom]". Rinshō Shinkei-gaku = Clinical Neurology. 49 (4): 179–85.doi:10.5692/clinicalneurol.49.179. PMID 19462816. 13. Jump up^ Kumar S (Mar 2004). "Recurrent seizures: an unusual manifestation of vitamin B12 deficiency". Neurology India. Neurologyindia. com. 52 (1): 122–123. PMID 15069260. 14. Jump up^ Mustafa TAŞKESEN; Ahmet YARAMIŞ; Selahattin KATAR; Ayfer GÖZÜ PİRİNÇÇİOĞLU; Murat SÖKER. "Neurological presentations of nutritional vitamin B12 deficiency in 42 breastfed infants in Southeast Turkey" (PDF). Turk J Med Sci. 41 (6): 1091–1096. Retrieved 2013-12-29. 15. Jump up^ Yavuz H (Sep 2008). "'Vitamin B12 deficiency and seizures'". Developmental Medicine and Child Neurology (Open access). 50 (9): 720. doi: 10.1111/j.1469-8749.2008.03083.x.PMID 18754925Abstract
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