Title: Aggressive Angiomyxoma – A Rare Tumor Often Misdiagnosed

Authors: Dr Asha Chandran, Dr Nivedita, Dr Bupathy, Dr Poomalar, Dr Srivani

 DOI: https://dx.doi.org/10.18535/jmscr/v10i10.15

Abstract

Aggressive Angiomyxoma is a rare mesenchymal tumour which is locally invasive most commonly occurring in women of reproductive age group with high chance of recurrence. This paper reports a case of 46 year old female with right vulvar swelling and 35 year old female with mass descending per vaginum both of these patients underwent surgical excision and histopathology reported as aggressive angiomyxoma. In view of high chance for recurrence patient is being followed up every 6 months.

Keywords: aggressive angiomyxoma, vulval swelling, mesenchymal tumour

References

  1. Kura MM, Jindal SR, Khemani UN. Aggressive angiomyxoma of the vulva: An uncommon entity. Indian Dermatol Online J. 2012 May;3(2):128-30.
  2. Behranwala KA, Thomas JM. 'Aggressive' angiomyxoma: a distinct clinical entity. Eur J SurgOncol. 2003 Sep;29(7):559-63.
  3. Siassi RM, Papadopoulos T, Matzel KE. Metastasizing aggressive angiomyxoma. N Engl J Med. 1999 Dec 2;341(23):1772.
  4. Steeper TA, Rosai J. Aggressive angiomyxoma of the female pelvis and perineum. Report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm. Am J Surg Pathol. 1983 Jul;7(5):463-75.
  5. Mandal S, Dhingra K, Roy S, Khurana N. Aggressive angiomyxoma of the vulva presenting as a pedunculated swelling. Indian J Pathol Microbiol. 2008 Apr-Jun;51(2):259-60.
  6. Qi S, Li B, Peng J, Wang P, Li W, Chen Y, Cui X, Liu C, Li F. Aggressive angiomyxoma of the liver: a case report. Int J ClinExp Med. 2015 Sep 15;8(9):15862-5.
  7. Geng J, Cao B, Wang L. Aggressive angiomyxoma: an unusual presentation. Korean J Radiol. 2012;13:90-3
  8. Chan IM, Hon E, Ngai SW, Ng TY, Wong LC. Aggressive angiomyxoma in females: is radical resection the only option? Acta Obstetriciaet Gynecologica Scandinavica. 2000;79:216-20.
  9. Nucci MR, Fletcher CD. Vulvovaginal soft tissue tumours: update and review. Histopathology. 2000 Feb;36(2):97-108.
  10. Salman MC, Kuzey GM, Dogan NU, Yuce K. Aggressive angiomyxoma of vulva recurring 8 years after initial diagnosis. Arch Gynecol Obstet. 2009 Sep;280(3):485-7.
  11. Q. Wei, J.Liu and J.J.Feng, Clinicopathological analysis of aggressive angiomyxoma,” Zhongua Yi XueZaZhi, vol,92 no22pp.1553-1555,2012
  12. Fetsch JF, Laskin WB, Lefkowitz M, Kindblom LG, Meis-Kindblom JM. Aggressive angiomyxoma: aclinico pathologic study of 29 female patients. Cancer 1996; 78:79-90
  13. Dierickx I, Deraedt K, Poppe W, Verguts J. Aggressive angiomyxoma of the vulva: a case report and review of literature. Arch Gynecol Obstet. 2008 Jun;277(6):483-7.
  14. Haldar K, Martinek IE, Kehoe S. Aggressive angiomyxoma: a case series and literature review. Eur J Surg Oncol. 2010 Apr;36(4):335-9.
  15. Sengupta SK, Bhattacharyya SK, Saha SP, et al. Recurrent aggressive angiomyxoma of the vulva—a rare presentation. J Clin Diagn Res. 2014;8(5):OD01–2.
  16. Blandamura S, Cruz J, Faure Vergara L, Machado Puerto I, Ninfo V. Aggressive angiomyxoma: a second case of metastasis with patient's death. Hum Pathol. 2003 Oct;34(10):1072-4.
  17. Sereda D, Sauthier P, Hadjeres R, Funaro D. Aggressive angiomyxoma of the vulva: a case report and review of the literature. Journal of Lower Genital Tract Disease. 2009 Jan;13(1):46-50.
  18. Sozutek A, Irkorucu O, Reyhan E, Yener K, Besen AA, Erdogan KE, Gonlusen G, Doran F. A Giant Aggressive Angiomyxoma of the Pelvis Misdiagnosed as Incarcerated Femoral Hernia: A Case Report and Review of the Literature. Case Rep Surg. 2016; 2016:9256749.

Corresponding Author

Dr Asha Chandran

PG, Dept. of OBG, SMVMCH, Pondicherry