Details
Category: Volume 08 Issue 11 November 2020
Hits: 907

Title: Clinico-etiological profile of new onset seizures in children admitted at a tertiary referral hospital

Authors: Peruru Latheesh Kumar, Alka Bhambri, Vedika Bhat

 DOI: https://dx.doi.org/10.18535/jmscr/v8i11.85

Abstract

Background: Seizure is one of the commonest neurological disorder and also a common cause of hospitalization in adolescence with significant morbidity and mortality.

Materials & Methods: This was a prospective study conducted in Pediatrics department, RMCH, Bareilly, UP among the admitted patients from 1st Nov 2018-31st Oct 2019 among 3months to 15year age group. Age, sex, type of seizure, associated complaints, clinical examination, laboratory investigations, neuroimaging, EEG findings were interpreted and clinic-etiological profile was made.

Results: Incidence of new onset seizures was common in older children with male predominance and GTCS being the most common type of seizure followed by focal seizures. Fever was the most common associated symptom. Most commonly CNS infection followed by seizure disorder, intracranial space occupying lesions predominantly NCC, febrile seizures, metabolic disorders were the etiologies found.

Conclusion: CSF analysis, EEG, Neuroimaging plays an important role in evaluating the seizure etiology and thorough history and clinical evaluation is very important before undergoing investigations. clinico-etiological profile of seizures can help in better understanding of the disease and help in better management. Larger sample size and long term follow up is required for the better understanding of the etiologies of seizures in context of a developing country.

References

  1. Adhikari S, Sathian B, Koirala DP, Rao KS. Profile of children admitted with seizures in a tertiary care hospital of Western Nepal. BMC pediatrics.2013; 13(1):43.
  2. Singh RD, Suryavanshi S. A hospital-based study on clinicoetiological profile of seizures in children–a Kanpur (UP, India) experience. International Journal of Contemporary Medical Research. 2016;3:3003-3007.
  3. Martindale JL, Goldstein JN, Pallin DJ: Emergency department seizure epidemiology. Emerg Med Clin North Am 2011;29(1):15–27.
  4. Friedman MJ, Sharieff GQ: Seizures in children. Pediat Clin North Am 2006;53: 257–277.
  5. Hauser WA: The prevalence and incidence of convulsive disorders in children. Epilepsia 1994;35(suppl 2): S1–S6.
  6. Idro R, Gwer S, Kahindi M: The incidence, aetiology and outcome of acute seizures in children admitted to a rural Kenyan district hospital. BMC Pediatr 2008;8:5.
  7. Chen CY, Chang YJ, Wu HP: New-onset Seizures in Pediatric Emergency. Pediatr Neonatol 2010;51(2):103–111.
  8. Murthy JMK, Yangala R: Acute symptomatic seizures — incidence and etiological spectrum: a hospital-based study from South India. Seizure 1999;8:162–165.
  9. Huang CC, Chang YC, Wang ST: Acute Symptomatic Seizure Disorders in Young Children-A Population Study in Southern Taiwan. Epilepsia 1998;39(9):960–964.
  10. Basu S, Ramchandran U, Thapliyal A: Clinical profile and outcome of Pediatric neuro-cysticercosis: A study from Western Nepal. J PediatrNeurol2007;5:45–52.
  11. Rayamajhi A, Singh R, Prasad R, Khanal B, Singhi S: Study of Japanese encephalitis and other viral encephalitis in Nepali children. Pediatr Int 2007;49 (6):978–984.
  12. Allen Hauser W, Beghi E: First seizure definitions and worldwide incidence and mortality. Epilepsia 2008;49(Suppl. 1):8–12.
  13. Geerts A, Arts WF, Stroink H, Peeters E, Brouwer O, Peters B, et al: Course and outcome of childhood epilepsy: A 15-year follow-up of the Dutch Study of Epilepsy in Childhood. Epilepsia 2010;51(7):1189–1197.
  14. Bautovich T, Numa A: Role of head computed tomography in the evaluation of children admitted to the paediatric intensive care unit with new-onset seizure. Emerg Med Australas 2012;24(3):313–320.
  15. Sharma S, Riviello JJ, Harper MB, Baskin MN: The role of emergent neuroimaging in children with new-onset afebrile seizures. Pediatrics 2003;111(1):1–5.
  16. Chaudhary N, Gupta MM, Shrestha S, Pathak S, Kurmi OP, Bhatia BD et al. Clinicodemographic Profile of Children with Seizures in a Tertiary Care Hospital: A Cross-Sectional Observational Study. Neurology research international. 2017; 2017.
  17. Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia.2017;58(4):522-30.
  18. Kliegman RM, Behrman RE, Stanton BF. Nelson Textbook of Pediatrics, 20th ed. Philadelphia: Elsevier; 2016. 27, The Nervous System:2791−
  19. Kliegman RM, Behrman RE, Stanton BF. Nelson Textbook of Pediatrics 20th ed. Philadelphia: Elsevier; 2016. 727, Laboratory Medicine:3460−

Corresponding Author

Peruru Latheesh Kumar