Title: Chronic Kidney Disease -A Forgotten Comorbidity in COPD
Authors: Dr Aditha Cibi Chakkravarthi T V, Prof. Dr S. Balasubramaniyan.M.D., Dr N.Paari M.D.
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.78
Abstract
Aim and Objective: To study the incidence of chronic kidney disease among patients with chronic obstructive pulmonary disease.
Methods: This is a prospective observational study conducted from November 2018 to October 2020. A total of 50 patients, diagnosed as COPD in ICU, IMCU, Ward of RMMCH were included the study after satisfying the inclusion and exclusion criteria. All the patients were subjected to clinical examination. Investigated with serum urea, creatinine, pulmonary function tests, abdominal ultrasound and EGFR calculation.
Result: Among the study population of 50 patients, 37(74%) of them had normal renal function, 13(26%) had chronic kidney disease. Among them 9(18%) had overt renal failure (eGFR<60, Creatinine >1.2) and 4(8%) had concealed renal failure (eGFR<60, Creatinine <1.2)
- Incidence of chronic kidney disease was more among males (52.6%) in comparison to females (9.7)
- Incidence of chronic kidney disease was found to be more among age 60 – 70(29%)
- Incidence of chronic kidney disease (36.1%) was more in smokers with pack years of more than 40.
Conclusion: Results from our study shows the increased incidence of chronic kidney disease both overt and concealed variety among patients with COPD.
Keywords: Chronic Kidney Disease (CKD), Chronic Obstructive Pulmonary Disease (COPD).
References
- Ibrahim I. Elmahallawy a,*, Mahmoud A Qora b Egyptian Journal of Chest Diseases and Tuberculosis (2013) 62, 221–227.
- DOI 10.1378/chest.09-1710 Chest 2010;137;831-837; Prepublished online November 10, 2009; Investigators Extrapulmonary Consequences of COPD in the Elderly Study Battaglia, Giuseppe Paglino, Vincenzo Bellia and on behalf of the Raffaele Antonelli Incalzi, Andrea Corsonello, Claudio Pedone, Salvatore.
- Chandra, J.A. Stamm, P.M. Palevsky, et al, The relationship between pulmonary emphysema and kidney function in smokers, Chest 11 (2012) 1456.
- Palange, Renal and hormonal abnormalities in chronic obstructive pulmonary disease (COPD), Thorax 53 (1998) 989–991.
- Satarug, P. Ujjin, Y. Vanavanitkun, et al, Effects of cigarette smoking and exposure to cadmium and lead on phenotypic variability of hepatic CYP2A6 and renal function biomarkers in men, Toxicology 204 (2004) 161–173.
- J. Sevenoaks, R.A. Stockley, Chronic obstructive pulmonary disease, inflammation and co-morbidity - a common inflammatory phenotype?, Respir Res. 7 (2006) 70.
- B. Soriano, G.T. Visick, H. Muellerova, N. Payvandi, A.L. Hansell, Patterns of comorbidities in newly diagnosed COPD and asthma in primary care, Chest 128 (4) (2005) 2099 - 2107.