Title: Study on Microalbuminuria in Newly Diagnosed Hypertensive Patients
Authors: Marrapu Venkata Vivek, Dr K Indira Devi MD, Dr T Manasa, Dr Y Pranathi
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.74
Abstract
Background: Hypertension is one of the most frequent diagnosis in hospitalized/outpatients in our country with significant morbidity and mortality. Microalbuminuria has important cardiovascular implications in hypertensive patients. It is known to occur independently in diabetes mellitus and hypertension. Microalbuminuria is an independent risk factor of target organ damage like hypertensive retinopathy, abnormality of left ventricular function. It indicates the severity of the disease and has been considered an important prognostic indicator.
Objectives
❖ To observe microalbuminuria in newly diagnosed hypertensives
❖To study the relationship between microalbuminuria and target organ damage(left ventricular hypertrophy)
Hundred hypertensive cases are evaluated for microalbuminuria. Microalbuminuria was measured in these patients by immunoturbidimetric assay.
Results: Significant microalbuminuria was observed to occur in hypertensive patients. The prevalence of microalbuminuria in this study is 32%. A positive correlation is noted between microalbuminuria and target organ damage. It was observed that there is a significant correlation between the prevalence of microalbuminuria and the presence of LVH (P < 0.05) in hypertensive patients.
Conclusion: Significant microalbuminuria was found to occur in newly detected hypertensive patients. This positive correlation between microalbuminuria and target organ damage in hypertensive patients calls for further studies with greater sample size.
Keywords: Microalbuminuria; Hypertension; Target organ damage.
References
- Forouzanfar MH et al. Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990-2015. JAMA 2017 Jan 10; 317:165
- Aram V. C., George L. B., Henry R. B., William C.C., LeeA. G., Joseph L.I. et al. The Seventh Report of the Joint National Committee on Prevention, Detection ,Evaluation& Treatment of High Blood Pressure; JAMA: 2003; 289:2560-2571
- Kearney PM, Whelton M, Reynolds K, Muntner, Whelton PK, He J. Global burden of hypertension:analysis of worldwide data. Lancet 2005 Jan 15-21.365(9455):217-23.
- Bakris gl, ihobanian et al. The seventh report of joint national committee on Prevention, detection, evaluation and treatment of blood pressure. The NC 7 Report JAMA289:2560, 2003.
- Guidelines committee. 2003 ESH ESC guidelines for management of arterial hypertension J Hypertens 2003; 21: 104 -53.
- Meerzon, FZ: The Myocardium in Hyperfunction, Hypertrophy and Heart Failure, Circulation : Vol.25, 1-163,1969.
- HithaB, Pappachan J, Pillai H, Sujathan P, Hitha B, Pappachan J, Pillai H, Sujathan P, Ramakrishna C, Jaya Prakash KMicroalbuminuria in Patients with Essential Hypertension and its Relationship to Target Organ Damage : An Indian Experience . Saudi J Kidney Dis Transpl. 2008;19(3):411-19.