Title: A Study of Correlation of Peradeniya Organophosphorus Scale (POP) and Serum Amylase Level in Assessing the Clinical Severity and Outcome of Organophosphorus Compound Poisoning
Authors: Dr Sindhu Malini.B, Prof. Dr Ramakrishna Rao. M, Prof. Dr Periyasamy S
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.65
Abstract
Background: Organophosphorus compound (OPC) poisoning is common in developing countries like India. In the recent times, POP scale and serum amylase levels are being used as a marker to assess the clinical severity of OPC poisoning. In the present study, patient’s clinical scoring by POP scale and serum amylase levels were estimated and its correlation with the clinical severity and outcome of OPC poisoning were established.
Aim of the study: To assess the outcome of Organophosphorus poisoning in relation to the serum amylase levels and POP (Peradeniya Organophosphorus) scale
Materials and Methods: A hospital based observational study was conducted in Rajah Muthiah Medical College from November 2018 to June 2020 in Medical Care Units. A total of 100 patients who met the selection criteria were included in the present study. At the time of admission, patient’s clinical scoring using POP scale was done. At the initial presentation and after 48 hours of admission, serum amylase levels were estimated.
Statistical Methods: Statistical analysis was done using software’s like SPSS version 23.0, MEDCOLC, Microsoft excel 2019.
Results: In this study, themean serum amylase level was 268.65 IU/L. The mean amylase level was 282.32 IU/L in the non survivors. POP scoring and serum amylase levels correlated directly with the severity of OP poisoning and mortality with a statistically significant p value of <0.001
Conclusion: Serum amylase level and Peradeniya organophosphorus scale (POP) correlated well with the clinical severity of OPC poisoning and are better predictors of the outcome, which were either recovery or death. Several studies on OPC poisoning were reported in the literature; however consensus is yet to be established on the role of serum amylase level and POP scale in OPC poisoning
Keywords: Organophosphorus compound (OPC) poisoning, Peradeniya Organophosphorus poisoning (POP) scale, Serum Amylase, Respiratory Failure, Ventilator Support.
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