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Category: Volume 08 Issue 11 November 2020
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Title: Immunohistochemistry Profile of Breast Cancer Patients from 2010 to 2014 in National Cancer Institute, Misurata, LIBYA

Authors: R. Elamyal, M. Elfagieh, Naji Zubia and W. Zwawi

 DOI: https://dx.doi.org/10.18535/jmscr/v8i11.18

Abstract

Introduction: breast cancer is the most common cancer in women. More than one million women are affected by this disease worldwide. Estrogen receptor (ER), progesterone receptor (PR) and Her-2 (Human Epidermal growth factor receptor) analysis have been accepted as established procedures in the routine management of patients with breast cancer.

Aim of our study is to to evaluate the estrogen receptor (ER), progesterone receptor (PR) and Her-2  expression in breast carcinomas by immunohistochemistry and clinicopathological parameters like patient’s age, histological grade in the patients registered in our institute between 2010 to 2014.

Methods: retrospective study of 78 female invasive breast carcinomas registered in our Institute from January 2010 to Dec 2014.

Results: the age of the patients ranged from 24 to 80 years, with a mean of 48.5, and the majority of the tumors were T2 invasive ductal carcinoma. Triple-negative breast cancers constituted 25 % of our cases and were most commonly grade 2. So we conclude that our group has a smaller number of patients but generally the hormonal receptor expression appears to be lower in our group of patients compared to the West. Further larger size studies are needed for better evaluation.   

Keywords:  Breast, triple negative.

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Corresponding Author

R.Elamyal

Surgical Oncology Department, National Cancer Institute, Misurata, LIBYA