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Category: Volume 08 Issue 05 May 2020
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Title: Study of Adiponectin and Leptin Levels in Patients of COPD and Its Correlation with Severity and Acute Exacerbation of Disease

Authors: Dr Adnan Khan, Dr Geeta Kampani

 DOI: https://dx.doi.org/10.18535/jmscr/v8i5.49

Abstract

 

Background: COPD is associated with inflammation which leads to acute exacerbation and causes extra pulmonary manifestations of the diseases. Elevated levels of CRP, fibrinogen, leukocyte counts are inflammatory markers associated with COPD.

Adiponectin and leptin are biomarkers of inflammation which can be used to assess disease activity and severity in COPD patients.

Aims:  To compare the adiponectin and leptin levels during acute exacerbation and remission in patients of COPD & correlate the levels with severity of disease.

Methods: It was a hospital based case control study conducted in VMMC and Safdarjung Hospital, New Delhi. It was conducted on 60 patients of COPD & 30 controls. Adiponectin & leptin levels were measured on admission and 7 days after discharge during remission. Severity of COPD was assessed by GOLD guidelines. Acute exacerbation was defined by Anthonisen criteria. Patients were considered to be in remission if they do not require increased doses of bronchodilator, antibiotics or steroids.

Result: Leptin levels were higher in cases than control on admission 21.12 v/s 4.96. Adiponectin levels were also higher in cases than control on admission 5.91 v/s 3.17.  Leptin levels were higher on admission, during acute exacerbation 21.12 than on remission 10.91. Adiponectin levels were higher on remission 7.11 than on admission. L/A ratio was higher on admission 3.71 v/s remission 1.74. Adiponectin levels correlate negatively with FeV1/FVC with r value of -0.005 but the correlation was not statistically significant. Serum leptin levels also correlates negatively with FeV1/FVC r value -0.051 but was not significant statistically.

Conclusion: Adiponectin & leptin levels are raised in cases of COPD compared to controls. Leptin levels are higher during acute exacerbation than remission whereas adiponectin levels are higher during remission. Adiponectin & leptin levels correlate negatively with severity of COPD but the correlation is not statistically significant.

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Corresponding Author

Dr Adnan Khan

Postgraduate Resident, Department of General Medicine, VMMC & SJH