Title: Platelet Count in Cases of Plasmodium Vivax Malaria- A 5 Year Retrospective Study

Authors: Debosmita Bhattacharyya, Achintya Bhattacharyya

 DOI: https://dx.doi.org/10.18535/jmscr/v8i4.95

Abstract

 

Background: Malaria is a major health problem in India even today with increased morbidity and mortality. Among the various types of malaria, Plasmodium vivax seems to be the most prevalent one. This study was undertaken to find out the effect of malaria on the platelet count of the patients.

Aims: The aim of this study is to note the changes in platelet count that can be found in the respective cases of plasmodium vivax malaria.

Materials and Methods: The study was conducted over a period of 5 years which included 311 cases of Plasmodium vivax.  Their platelet count was measured manually by a haemocytometer.

Results: It has been found that in 311 cases, the level of platelet varies in various samples. The most common manifestation was thrombocytopenia. Out of 311 patients, 271 were found to have a low platelet count. The rest however had platelet count within normal range.

Conclusion: Though malaria is predominantly a disease affecting the red blood cells in a human body, we see that the platelet count is also altered in the disease. The commonest presentation being thrombocytopenia. So, we can conclude that in endemic region, malaria is usually associated with thrombocytopenia.

Keywords: Plasmodium vivax, thrombocytopenia, malaria.

References

  1. WHO- Regional and global trends in burden of malaria cases and deaths; World Malaria Report 2019 4th December, pg xii-xiii.
  2. Guerra CA, Gikandi PW, Tatem AJ, Noor AM, Smith DI, et al- The limits and intensity of Plasmodium falciparum transmission: implications for malaria control and elimination worldwide; Plos Med 2008, 5: e38.
  3. Anstey NM, Russell B, Yeo TW, Price RN- The pathophysiology of vivax malaria; Trends Parasitol 2009, 25: 220-227.
  4. Lacerda MV, Mourao MP, Alexandre MA, Siqueira AM, Maghalhaes BM, et al -2012 Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systemic review on the contributions of the Brazilian literature; Malar J 2012, 11:12.
  5. Wickramasinghe SN, Abdalla SH- Blood and bone marrow changes in malaria; Clin Haematol 2000, 13: 277-299.
  6. Mc Morran BJ, Marshall VM, de Graaf C, Drysdale KE, Shabbar M, Smyth GK, et al- Platelets kill intererythrocytic malarial parasites and mediate survival to infection; Science 2009, 323: 797-800.
  7. Yamikani C, Kondwani K, Terrie T, Malcolm M- The Platelet count in Cerebral Malaria, Is it useful to the clinician ?; Am J Trop Med Hyg 2010, 83:48-50.
  8. Akhtar MN, Jamil S, Amjad SI, Butt AR, Farooq M- Association of malaria with thrombocytopenia; Ann King Edward Med Coll 2005, 11: 536-7.
  9. Patel U, Gandhi G, Friedman S, Niranjan S- Thrombocytopenia in malaria; J of National Med Assoc 2004, 96(9): 1212-14.
  10. Shaikh MA, Ahmed S, Diju IU, Yakta DE- Platelet count in malarial patients; J Ayub Med Coll Abbottabad 2011, 23(1): 143-45.
  11. Kar K, Bhatta A- Epidemiological profile of malaria cases admitted to a tertiary care centre of Odish; Journal of Academia and Industrial Research. 2015, vol 3, issue 11 April: 533-35.
  12. Coelho C Christina H, Lopes C.P S, Pimental D P Joao, Nogueira A. P, Costa TM Fabio, Siqueira MA, et al- Thrombocytopenia in Plasmodium vivax Malaria is related to platelets phagocytosis; Plos one. 2013 May, vol 8, issue 5, pg 1-7.
  13. Muddaih M, Prakash P.S - A study of clinical profile of malaria in a tertiary referral centre in South Canara; Vect. Borne dis 2006, 43(1): 29-33.)
  14. Joshi M and Gowardhan P - Retrospective analysis of malaria and its complications in a tertiary care centre in Central India; Asian J. Biom. Pharma. Res. Sci 2013, 3(20): 41-43.
  15. Skudowitz R, Katz J, Lurie A, et al- Mechanisms of thrombocytopenia in malignant tertian malaria; BMJ 1973, I:151-8.
  16. Looareesuwan S, Davis J, Allen D, et al- Thrombocytopenia in malaria; South Asian J Trop Publ 1993; 23:44-50.
  17. Kakar A, Bhoi S, Prakash V, Kakar S- Profound thrombocytopenia in Plasmodium vivax malaria;. Diagn Microbial Infect Dis 1999, 35: 243-4.
  18. Srivastava S, Ahmed S, Shirazi N, Verma K. S, Puri P- Retrospective analysis of vivax malaria patients presenting to tertiary referral centre of Uttarakhand; Acta Tropica 2011, 117: 82-85.
  19. Fernanda M, Bernardo S, Andrea T, Agnaldo L, Salua C, Cor J, Cristina F, Luzia H- Augmented plasma micro particles during acute Plasmodium vivax infection; Malaria Journal 2010, 9: 327-9.

Corresponding Author

Achintya Bhattacharyya

Variable Energy Cyclotron Centre