Title: A study on seroprevalence of Rubella IgG antibodies among antenatal women in a tertiary care centre in Kerala
Authors: Dr Nita Fazil, Dr Shoba Pillai, Dr Vibi Varghese, Dr J. Lancy
DOI: https://dx.doi.org/10.18535/jmscr/v8i4.78
Abstract
Rubella is a mild exanthematous fever characterised by transient macular rash that often goes unnoticed. It is of worldwide distribution. However, rubella infection in pregnant females can lead to grave consequences due to its teratogenicity. Rubella vaccine was included in the National Immunisation Programme only in 2017. Before that the vaccine was available in the private sector. Even after 100% immunisation, there were changing trends in IgG antibody levels in various groups of people. A study was conducted in the department of Microbiology at Government Medical College, Ernakulam to find out the seroprevalence of Rubella IgG antibodies among pregnant women attending the OPD of the Obstetric and Gynaecology department during a period of one year from May 2017 to April 2018 by doing a quantitative ELISA.A total number of 200 blood samples were tested. Majority of the patients were unimmunised (60%) and the seropositivity was 69.17% and the seropositivity among immunised women was 39.5%.
Keywords: Rubella, Quantitative ELISA, IgG antibody.
References
- Dewan P, Gupta P.Burden of Congenital Rubella Syndrome (CRS) in India: A systematic Review Indian Pediatr; May 2012;49(5):377-99.
- Baschirotto, P.T, Krieger M.A and Foti L. Preliminary multiplex microaaray IgG immunoassay for the diagnosis of Toxoplasmosis and Rubella. Mem Inst Oswaldo Cruz, Jun 2017;112(6):428-436.
- Lin C.C, Yang C.Y, Shih Y.L. et al. Persistance and Titer Changes of Rubella Virus Antibodies in Primiparous Women who had been vaccinated with strain RA 27/3 in Junior High School. Clin Vaccine Immune. Dec 2011; 19(1):1-4.
- Mangala Prasad .V, Willows S.D, Fokine.A.et al. Rubella virus capsid protein structure and its role in virus assembly and infection. Proceedings of the National Academy of Sciences of the United States of America, Dec 2013;110 (50):20105-20110.
- E, Chen.M, Bera.J, et al. Analysis of whole genome sequences of 16 strains of Rubella virus from the United States, 1961-2009.Virology journal, Jan 2013; 10(1):10-32.
- Standardisation of the nomenclature for genetic characyeristics of wild type Rubella viruses.2005; Wkl Epideol Rec 88, 337-43.
- WHO Strategic plan for measles elimination and Rubella and Congenital Rubella Syndrome Control in the South East Asia Region 2014-2020.
- WHO-recommended surveillance standard of Rubella and Congenital Rubella Syndrome. 2014.
- Brooks F.G, Butel J.S, Morse S.A, Melnick J.L, Jawetz E, Adelberg E.A (2004). Rubella virus. In: Medical Micro-biology, 23rd (edn).Chapter 40:566-568.
- Z, Rivailler. P et al. Evolutionary analysis of Rubella viruses in mainland China during 2010-2012: endemic circulation of genotype 1E and introduc-tions of genotype 2B.Nature Research Journal. Jan 2015.Scientific Reports 5, Article number:7999.
- Wandinger k, Saschenbecker S, Stainhagen K et al.Diagnosis of recent primary Rubella virus infections: significance of glycoprotein based IgM serology, IgG avidity and immunoblot analysis. Journal of Virological Methods, Jun 2011;174(1-2):85-93.
- Gupta E, Dar L and Broor. S. Seroprevalence of Rubella in pregnant women in Delhi, India. The Indian Journal of Medical Research, 2006;123(6),833-5.
- Control and prevention of Rubella: evaluation and management of suspected outbreaks, Rubella in pregnant women and surveillance for Congenital Rubella Syndrome. MMWR Morb Mortal Wkly Rep 2001; 50:1-23.
- Zanga J, Mbanzulu M.K, Kabasele A.F et al. Rubella seroprevalence and real time PCR detection of RUBV among Congolese pregnant women.BMC Infectious Diseases, April 2017;17(1):1.
- Singla N, Jindal N, Aggarwal A. The seroepidemiology of Rubella in Amritsar (Punjab).IJMM, 2004; 22(1):61-63
- Padmaja M, Radhakrishna P.M, Sam J.V. Seroprevalence of immunity to Rubella in pregnant women. The National Medical Journal of India.2010;23(4):248-9.