Title: Association of Immune thrombocytopenia with Celiac Disease in a young female
Authors: Dr Nishant Jindal, Dr Madhulika Sharma, Dr S V Agarwal, Dr Sumesh Nirwan
DOI: https://dx.doi.org/10.18535/jmscr/v8i4.77
Abstract
A 18 year young female who was known case of celiac disease presented with epistaxis, petechial rash and menorrhagia. Routine workup revealed anemia with severe thrombocytopenia. Bone marrow investigation revealed immune thrombocytopenia. Celiac disease (CD) and Immune thrombocytopenic purpura (ITP) may occur together as a result of similar autoimmune mechanisms.
Keyword: celiac disease, immune thrombocytopenic purpura, autoimmune.
References
- Fasano A. Clinical presentation of celiac disease in the pediatric population. Gastroenterology 2005;128:S68–73.
- Halfdanarson TR, Litzow MR, Murray JA. Hematologic manifestations of celiac disease. Blood 2007;109:412–21.
- Stepniak D, Koning F. Celiac disease-sandwiched between innate and adaptive immunity. Hum Immunol 2006;67:460–8.
- Zanoni G, Navone R, Lunardi C, Tridente G, Bason C, Sivori S, et al. In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. PLoS Med 2006;3:e358.
- Aslam R, Speck ER, Kim M, Crow AR, Bang KW, Nestel FP, et al. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factoralpha production in vivo. Blood 2006;107:637–41.
- Biagi F, Klersy C, Balduzzi D, Corazza GR. Are we not overestimating the prevalence of coeliac disease in the general population? Ann Med 2010;42:557–61.