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Category: Volume 08 Issue 04 April 2020
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Title: Corona Virus Outbreak

Authors: Dr Sumeet Narain, Dr Mayank Kumar Singh, Dr Dvijendra Nath

 DOI: https://dx.doi.org/10.18535/jmscr/v8i4.63

Abstract

   

Introduction

Very recently, a novel beta‐CoVs coronavirus (2019‐nCoV) originating from the province of Wuhan, China, has been causally linked to severe respiratory infections in humans.[1] As of today 28/03/2020, there are 517678 confirmed cases of covid-19 in the world, involving 202 countries and resulting in almost 26,495 deaths worldwide[2]. India has 819 positive cases resulting in 19 deaths. This article will give a panorama view of this new emerging infection. This corona virus infection is rapidly evolving and much of the details and research is required for the same.

History

Coronaviridae (CoVs) are the largest known single‐stranded RNA viruses. Coronaviruses are members of the subfamily Coronavirinae in the family Coronaviridae and the order Nidovirales (International Committee on Taxonomy of Viruses).[3] This subfamily consists of four genera-

  1. Alpha‐CoVs- responsible for gastrointes-tinal disorders in human, dogs, pigs, and cats;
  2. Beta‐CoVs- including the Bat coronavirus (BCoV), the human severe acute respiratory syndrome (SARS) virus and the Middle Eastern respiratory syndrome (MERS) virus
  3. Gamma‐CoVs- infecting birds
  4. Delta CoVs- infecting birds.[1,3]

References

  1. Ceraolo C, Giorgi FM. Genomic variance of the 2019‐nCoV coronavirus. J Med Virol. 2020; 92: 522–528. https://doi.org/10.1002/jmv.25700
  2. https://www.who.int/emergencies/diseases/novel-coronavirus-2019
  3. Cui, J., Li, F. & Shi, Z. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol 17, 181–192 (2019). https://doi.org/10.1038/s41579-018-0118-9
  4. https://faq.coronavirus.gov/spread/#how-does-the-virus-spread
  5. Andersen, K.G., Rambaut, A., Lipkin, W.I. et al. The proximal origin of SARS-CoV-2. Nat Med (2020). https://doi.org/10.1038/s41591-020-0820-9
  6. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200121-sitrep-1-2019-ncov.pdf?sfvrsn=20a99c10_4
  7. https://www.who.int/docs/default-source/wrindia/india-situation-report-1.pdf?sfvrsn=5ca2a672_0
  8. https://www.who.int/docs/default-source/ wrindia/india-situation-report-2.pdf? sfvrsn=962f294b_0
  9. https://www.who.int/docs/default-source/wrindia/situation-report/india-situation-report-4fc11fed6bd464083b4ce93b26097391e.pdf?sfvrsn=d257be4b_2
  10. https://www.who.int/docs/default-source/wrindia/situation-report/india-situation-report-7.pdf?sfvrsn=cf4a7312_2
  11. https://www.who.int/docs/default-source/wrindia/situation-report/india-situation-report-8bc9aca340f91408b9efbedb3917565fc.pdf?sfvrsn=5e0b8a43_2
  12. https://www.who.int/docs/default-source/wrindia/situation-report/india-situation-report-9.pdf?sfvrsn=40999c3c_2
  13. https://www.who.int/docs/default-source/ coronaviruse/situation-reports/20200221-sitrep-32-covid-19.pdf?sfvrsn=4802d089_2
  14. Hussin A. Rothan and Siddappa N. Byrareddy, Journal of Autoimmunity, https://doi.org/10.1016/j.jaut.2020.102433
  15. Huang C et al.Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395 (10223): 497-506.
  16. Chan N et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet.2020; 395 (10223):507-13.
  17. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061–1069. doi:10.1001/jama.2020.1585
  18. Huang et al . Clinical features of patients infected with 2019 novel coronavirus in whuan, china. The Lancet 2020;395 (10223):497-506
  19. Michelle L.First case of 2019 Novel coronavirus in the United States . N engl J Med.2020;382(1):929-36
  20. Hongzhou Lu. Drug treatment options for the 2019-new coronavirus (2019-ncov). Bio Science Trends .2020;14(1):69-71
  21. Sun P, Lu X, Xu C, Sun W, Pan B. Understanding of COVID‐19 based on current evidence. J Med Virol. 2020;1–4.https://doi.org/10.1002/jmv.257224|SUN ET AL.
  22. https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention. html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fprepare%2Fprevention.html
  23. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public

Corresponding Author

Dr Sumeet Narain

Junior Resident, Department of Pathology, MLB Medical College, Jhansi