Title: Association of Tuberculosis with Other Infections in Post Renal Transplant Recipients- A Retrospective Study

Authors: Karan S. Thakur, Deepesh B Kenwar, Ashish Sharma, Sarabpreet Singh, Purnima Patial

 DOI: https://dx.doi.org/10.18535/jmscr/v8i4.57

Abstract

   

The number of Renal Transplantations is increasing among developing nations. Tuberculosis is a big health problem in endemic countries. TB is a leading cause of morbidity and mortality in endemic countries and more common in kidney transplant patients. Renal transplant recipients are at risk for reactivation of latent Mycobacterium tuberculosis infection and primary infections. So relative risk of TB is high in organ transplantation. Other infections for example CMV, Pneumocystis carinni downgrade host immunity and may activate occult TB. Most of the cases of TB and other infections occur in the initial months of transplant surgery and during most intense period of immunosuppressant drugs. Risk of TB and associated infections depends on geographical regions also. TB is a barrier in successful long-term outcome in renal transplant. Thus this study tried to determine the association of post Renal Transplant TB with various co-infections.

Keywords: Renal Transplant, TB-Tuberculosis, CKD-Chronic Kidney disease.

References

  1. Kalra V, Agarwal SK, Khilnani GC, Tiwari SC, Kapil A, Gupta S et al. Spectrum of tuberculosis in renal transplant recipients in tropics. International Urology and nephrology 2005;37:551-59.
  2. Drobniewski FA, Ferguson J. Tuberculosis in renal transplant unit. Nephrology Dialysis Transplant 1996; 11: 768– 70.
  3. Canet E, Dantal J, Blancho G, Hourmant M, Coupel S. Tuberculosis following kidney transplantation. Nephrology Dialysis Transplantion 2011; 26: 3773–78.
  4. Jasmer RM, Nahid P, Hopewell PC. Latent tuberculosis infection. New English Journal Med 2002; 347: 1860–66.
  5. Malhotra KK, Dash SC, Dhawan IK. Tuberculosis and renal transplantation-observations from an endemic area of tuberculosis. Post Grad Med J 1986; 62: 359– 62.
  6. Subramanian A, Morris M. Mycobacterium tuberculosis Infections in Solid Organ Transplantation. American Journal of Transplantation 2013; 13: 68–76.

Corresponding Author

Purnima Patial