Title: Value of Single Widal test in Children for Diagnosis of Typhoid Fever

Authors: Dr Susanta Kumar Ghosh, Dr Santosh Kumar Saha, Dr Milia Islam

 DOI: https://dx.doi.org/10.18535/jmscr/v8i4.29

Abstract

   

Background: Typhoid is one of the medical illnesses that are contagious. S-caused infection in typhoid fever. S. and typhi. Paratyphi A is still a huge worldwide safety concern. This is difficult to treat typhoid fever scientifically because the signs frequently differ and appear close to those of other febrile diseases. Numerous studies are now possible in genetic, immunological, biochemical and microbiological settings.

Objective: To establish the relevance of widal test in the diagnosis of typhoid fever.

Method: This research was conducted at Tertiary Medical College Hospital, Dhaka from January 2016 to January 2018 to examine improvements in enteric fever clinical trends. The research has caused a minimum of 120 children aged 0 to 14 to be in typhoid fever. For all, 90 children had definite diagnosis, as shown by S isolation for typhoid or paratyphoid fever. or S typhi. Blood paratyphi and 30 were accused of harmful blood production but not typhoid fever, in scientific words. The Widal research was performed using the quick diaphragm agglutination process and was tested in accordance with the results from blood cultivation.

Results: Results showed that the accuracy of the widal tube and slide agglutination tests as used in the study in terms of sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 73%, 62%, 92% and 28%, respectively.

Conclusion: It is concluded that a large-scale test remains important as a typhoid fever diagnostics device, more flexible, cheaper and quicker than other molecular and serological studies.

References

  1. Thong KL, Puthucheary S, Yassin RM. et al. Analysis of Salmonella typhi isolates from Southeast Asia by pulsed-field gel electrophoresis. J Clin Microbiol. 1995;33:1938–1941
  2. Pang T, Buttha ZA, Finlay BB, Altwegg M. Typhoid fever and other salmonellosis: a continuing challenge. Trends Mi-crobiol. 1995;3:253–255
  3. Sur D, Ali M, Lorenz von S, Manna B, Deen JL, Acosta CJ, et al. Comparisons of predictors for typhoid and paratyphoid fever in Kolkata, India. BMC Public Health 2007; 7: 289.
  4. Bhutta Z.A, and K.M. Hendricks. 1996. Nutritional management of persistent diarrhoea in childhood: a perspective from the developing world. J PediatrGastrNutr., 22: 17-37
  5. Sridhar Rao, P.N.(2009) Widal Test [online] Available at: http://www.nucrokao.com/nucronotes/widal.pdf [Accessed 4 January, 2011]
  6. Lunette, E.H.; Balows, A.; Hauster, W.J. and Shadomym H.J. (1985) Manval of Clinical Microbiology. ASM: Washington, DC.
  7. Schroeder SA. Interpretation of serologic tests for typhoid fever. JAMA 1968; 206(4): 839-40.
  8. Sen A, Saxena SN. Critical assessment of the conventional Widal test in diagnosis of typhoid fever. Indian J Med Res 1969; 57(10): 1813-9.
  9. Parker MT. Enteric infection: Typhoid and para typhoid fever. In: Wilson GS, Miles AS, Parker MT. Topley and Wilson’s Principles of Bacteriology, Virology and Immunity, Vol III, 7th, London, Edward Arnold Publishers Limited, 1984. P. 843-9.
  10. Chang HR, Vladoianu IR, Pechere JC. Effects of ampicillin, ceftriaxone, pefloxacin, and trimethoprim – sulphamethox-azole on Salmonella typhi within human monocyte-derived macrophages. J Antimicrob Chemother 1990; 26: 689–94.
  11. Parry CM, Hien TT, Dougan G et al. Typhoid fever. N EngJMed 2002; 347: 1770-82.

Corresponding Author

Dr Susanta Kumar Ghosh

Associate Professor, Department of Pediatrics, Medical College for Women and Hospital, Uttara, Dhaka, Bangladesh