Details
Category: Volume 08 Issue 04 April 2020
Hits: 1281

Title: Juvenile Granulosa Cell Tumor: A Case Report

Authors: Lekshmi Vijayamohanan, Sarita Asotra, Kushla Pathania, Shikha Sharma, Aarti Dhatwalia

 DOI: https://dx.doi.org/10.18535/jmscr/v8i4.28

Abstract

   

Granulosa cell tumours (GCT) are rare sex cord stromal tumour, encompassing only 2% of all the ovarian tumours1. Only 0.1% of all ovarian tumours and 4-5% of GCT occur in children. Juvenile GCT(JGCT), a sub- type of ovarian sex cord stromal tumour has a favorable prognosis if diagnosed at an early stage.2 We present a case of a 19 year old female patient; presenting with symptoms of clitoromegaly, irregular menstrual cycles & hirsuitism.

Keywords: Juvenile Granulosa Cell Tumor, ovarian neoplasm, reticulin, sex-cord stromal, rare.

References

  1. Moid FY, Jones RV. “Granulosa cell tumour and mucinous cystadeno- ma arising in a mature cystic teratoma of the ovary: a unique case report and review of literature” Annals of Diagnostic Pathology. 2004; 8(2):96– 101
  2. Nikumbh DB,Suryawanshi KH,Chitale AM, Pagare P, Surana A.. Ovari- an juvenile granulosa cell tumour in childhood: uncommon gynecological malignancy. JOURNAL OF CLINICAL AND DIAGNOSTIC RE- SEARCH. 2014; 8:FL01-02. 10.7860/JCDR/2014/9510.4935
  3. Ashnagar A, Alavi S, Nilipour Y, et al. Massive ascites as the only sign of ovarian juvenile granulosa cell tumor in an adolescent: a case report and a review of the literature. Case Rep Oncol Med. 2013;2013:386725
  4. Anandpara KM, Aswani Y, Thakkar H, Hira P, Sathe PA. Juvenile Granulosa Cell Tumour of the Ovary with Unilocular Pure Cystic Presen- tation: A Case Report and Review of Literature. Pol J Radiol. 2016;81:120–124. Published 2016 Mar 21. doi:10.12659/PJR.896033
  5. Long JR, Danielson D. Juvenile granulosa cell tumor of the ovary. Ap- plied Radiology. 2008;1:44– 48
  6. Lack EE, Perez-Atayde AR, Murthy ASK, Goldtsein DP, Crigler JF, Vawter GF(1981) Granulosa theca cell tumors in premenarchal girls. A clinical and pathologic study of ten cases. Cancer (Phila) 48:1846-1854.
  7. Young RH, Scully RE(1984a) Ovarian Sertoli cell tumors. A report of ten cases. Int J Gynecol Pathol 2:349-363.
  8. Kanthan R, Senger J-L, Kanthan S. The multifaceted granulosa cell tu- mours-myths and realities: a review. ISRN Obstet Gynecol. 2012;2012:878635.
  9. Scully RE. Ovarian tumors. Am J Pathol. 1977;8:686–720.
  10. Powell JL, Otis CN. Management of advanced juvenile granulosa cell tumor of the ovary. Gynecol Oncol. 1997;64:282–4.
  11. Blaustein, A., Kurman, R. J., Ellenson, L. H., Ronnett, B. M., & Springer Nature. (2019). Blaustein's pathology of the female genital tract. Cham: Springer.
  12. Stall, Jennifer & Young, Robert. (2018). Granulosa Cell Tumors of the Ovary With Prominent Thecoma-like Foci: A Report of 16 Cases Em- phasizing the Ongoing Utility of the Reticulin Stain in the Modern Era. International Journal of Gynecological Pathology. 38. 1. 10.1097/PGP. 0000000000000508.
  13. Ehdaivand S Granulosa cell tumor - adult. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorgc- tadult.html.

Corresponding Author

Dr Sarita Asotra

Associate Professor, Department of Pathology, IGMC Shimla, Himachal Pradesh-.171001, India