Title: Comparison of C - reactive protein in normotensive & hypertensive type 2 diabetic patients
Authors: Randhir K.Pandey, Suresh Babu Kondaveeti, Manju Pandey, Madhuri Gupta
DOI: https://dx.doi.org/10.18535/jmscr/v7i9.131
Abstract
Background: The present study was aimed to comparison the C-reactive protein with microalbuminuria among type 2 diabetic subjects in hypertension.
Introduction: CRP production is part of the nonspecific acute-phase response to most forms of inflammation, infection and tissue damage. The association between CRP and hypertension could be related in part as follows: correlation between elevated CRP and arterial stiffness; association between CRP and metabolic syndrome, one of whose criteria is hypertension and the possibility that CRP may directly contribute to reduced nitric oxide synthesis in endothelial cells, leading to increased vascular resistance.
Material & Methods: The present study includes of 500 type 2 diabetic subject & divided into two groups based on hypertension. Biochemical parameter such as C-reactive protein (CRP) was analysed in the department of biochemistry of NIMS medical college. Hypertension was taken according to definition of WHO; as systolic blood pressure (SBP) ≥140 mmHg and diastolic (DBP) ≥90 mmHg.
Result: There was significant difference between the patient and control groups with regard to age, blood pressure, lipid profile, and CRP. The study also showed significant positive correlations between CRP, age and blood pressure.
Conclusion: The levels of CRP were elevated in hypertensive individuals, which suggests the possibility of an inflammatory pathogenesis in hypertension.
Keywords: C-reactive protein, normotensive, hypertension.
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