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Category: Volume 07 Issue 09 September 2019
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Title: Evaluation of Peripheral Neuropathy in Chronic Hepatitis C Infection

Authors: Khundrakpam Yoihenba, Chingakham Arunkumar, Th Suraj Singh, Th Bhimo Singh, N Biplab Singh, I Anil Singh

 DOI: https://dx.doi.org/10.18535/jmscr/v7i9.126

Abstract

  

Background: Chronic Hepatitis C infection is very common in Manipur, a north eastern state of India. The study has been undertaken to assess peripheral neuropathy and find out any correlation of it with different parameters of chronic hepatitis C patients. 

Materials and Method: This study was a cross sectional study of patients who were diagnosed as chronic HCV infected individuals in the Department of Medicine, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur. Comprehensive history, thorough clinical examination and all relevant routine investigation including HCV RNA quantitative and genotyping and nerve conduction velocity (NCV) were done for all patients.

Results: Among 31 patients of chronic HCV studied, peripheral neuropathy was more common in adults in the 4th decades. Peripheral neuropathy was observed in about 74.2% in which sensory involvement are more common. Axonal variety of neuropathy was maximum and most of the patients have lower limb involvement. Variables related to liver disease severity such as low platelet count, Child-Turcotte Pugh Score, presence of cirrhosis on ultrasound correlate well with the development of peripheral neuropathy. Presence of neuropathy is more common in group of patients whose viral is still detected in the blood.

Conclusion: Peripheral neuropathy affect 74.2% of patients of chronic HCV infection, most commonly involving sensory and axonal type of neuropathy in this study. There is positive correlation between the severity of neuropathy and increasing Child Class.

Keywords: Chronic HCV, peripheral neuropathy, sensory, axonal.

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Corresponding Author

Chingakham Arunkumar

Assistant Professor,  Department of General Medicine, Jawaharlal Nehru Institute of Medical Sciences, Porompat, Imphal, Manipur, India