Title: A Comparative Evaluation of Fosfomycin activity with other Antimicrobial agents against Enterobacteriaceae Uropathogen
Authors: Dr Ved Prakash Mamoria, Kajal Meena, Dr Richa Sharma
DOI: https://dx.doi.org/10.18535/jmscr/v7i9.110
Abstract
Urinary Tract Infection is the common bacterial diseases that affect a large part of the world’s population, in both hospitals and in the community. Escherichia coli, Klebsiella spp., and Proteus spp. are the uropathogens with the highest prevalence among patients with UTIs. The gender and sexual anatomy are among the major determinants of UTI. They are more common in women in comparison with men. In the present study, out of 591 Enterobacteriaceae isolates, majority of the urine specimens were from inpatients 377 (64%) than from outpatients 214 (36%). Out of 4176 urine specimens 591 (100%) Enterobacteriaceae isolates were obtained, of which 432 (73.09%) were Escherichia coli, followed by Klebsiella pneumoniae 97 (16.41%), Providenciarettgeri21 (3.55%), Proteus mirabilis 14 (2.37%), Enterobacter cloacae 12 (2.03%),Morganella morganii and Citrobacter koseri 6 (1.02%), Serratia marcescens 3 (0.51%). So total positive Enterobacteriaceae isolates were 591.Out of the 591 isolated patient’s majority of isolates were from female patients in the age group of 21-30 i.e. 102 (17.26%), followed by age group 31-40 i.e. 51(8.63%). In the present findings, also reported the sensitivity to fosfomycin was significantly higher in E. coli i.e. 419(97%), followed by Klebsiella pneumoniae 61 (62.9%). It concludes that Fosfomycin may be given empirically in patients suffering from UTI due to Enterobacteriaceae.
Keywords: UTI, E.coli, Sensitivity, Uropathogens.
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