Title: Structural changes in placenta of hypertensive pregnancies in North Indian Population

Authors: Dr Ratesh Kumar Munjal, Dr Nimisha Sharma, Dr Kunal Chawla

 DOI: https://dx.doi.org/10.18535/jmscr/v7i9.85

Abstract

  

Most important factor for fetalwell-being is placental growth. Villous volume contributes to main mass of placenta. Purpose of this study is to correlate villous changes in hypertension. Thirty placentae were collected from two colleges i.e. Government Medical College, Chandigarh and ESIC Medical College, Faridabad, and divided into two group i.e. normal placentae and placenta from hypertensive mothers. After morphological examination, histological examination was done with H& E stain. Villous volume was calculated with ‘Point Counting Technique’ as described by Mathur et al. Significant decrease in villous volume and other parameters were seen.

Keywords: Placenta, Chorionic Villi, Histomorphomtery, Hypertension.

References

  1. Jones CJP, Fox H. An ultrastructural and ultrahistochemical study of human placenta in maternal pre-eclampsia. Placenta, 1980; 1: 61 - 76.
  2. Rath G, Garg K et al.Vascular pattern of human placenta in complicated pregnancy,a corrosive cast study.Ann Nat Acad Med Sc(Ind),1994;30:17-22.
  3. Mathur S, Dasgupta P.A simple morphometric method for the study of placentae. Indian J Pathol Bacteriol 1974;17(4):205-210.
  4. Rath G, Garg K, Sood M. Insertion of umbilical cord to the placenta in hypertensive mothers. J Anat Soc India, 2000; 49(2): 149 -154.
  5. Damania KR, Salvi VS, Ratnaparki SK, Daftari SN. The placenta in hypertensive disorder in pregnancy. J Obst and Gynaecol Ind, 1989; 39: 28-31.
  6. Fox H. The significance of placental infarction in perinatal morbidity and mortality. Biologica Neonatorum; 1967 (b); 11: 87 - 105.
  7. Kalousek DK, Langlosis S. The effects of placental and somatic chromosomal mosaicism on foetal growth. In: Ward RHT, Smith SK, Donnai (eds), Early foetal growth and development, RCOG Press,1994;Pp 245-256.
  8. Yousonszai & Haworth. Placental dimensions and relations in pre-term and growth retarded infants. Am J Obst Gynaecol 1969;103: 265-271.
  9. Fox, H; The placenta in intra uterine growth retardation. In Ward RHT, Smith SK, Donnai D (Eds). Early foetal growth and development. RCOG Press, London, 1994; Pp: 223 -235.
  10. Udainia A, Bhagwat SS, Mehta CD. Relation between placental surface area, infarction and foetal distress in pregnancy induced hypertension with its clinical relevance. J Anat Soc Ind 2004, 53; 1: 27-30.
  11. Pretorius DH, Chau C, Poeltler DM, Mendoza A, Catanzarite VA, Hollenbach KA. Placental cord insertion, visualisation with prenatal ultrasonography. J Ultrasound Med, 1996; 15: 585 – 593.

Corresponding Author

Dr Kunal Chawla

Assistant Professor, Department of Anatomy, IGMC, Shimla, Himachal Pradesh