Title: An Observational Study to find out Frequency of Bronchial Asthma among Patients with Successful Treatment of Pulmonary Tuberculosis

Authors: Dr Surendra Kumar, Dr Sunil Kumar Agrawal

 DOI: https://dx.doi.org/10.18535/jmscr/v7i9.52

Abstract

    

Aim: To find out Frequency of Bronchial Asthma among post Tuberculosis patients with successful treatment of pulmonary tuberculosis (PTB).

Method: This is an observational study conducted at Chest department OPD at patna Medical College & Hospital. After completion of TB treatment for PTB patients still presenting with cough, dyspnea and recurent wheezing were send to speciality clinic of chest department. According to diagnostic criteria which was spirometry patients were either excluded or included in the study after recording of complete history, thorough examination. Social sciences (SPSS) version 17 were used to analyze the data.

Result: 230 patients were examined, interviewed and PFTSs were done. Males were 108(47%), females 122(53%) and Asthma was found in 70 (30%) of patients with 40 (57%) females and 30(43%) males. Maximum numbers of patients were between 15 and 45 years of age.

Conclusion: In patients with history of successfully treated PTB previously Bronchial asthma is a common problem. To established the exact mechanism a large randomised control study should be conducted.

References

  1. Holgate S.T., Polosa R. Treatment strategies for allergy and asthma. Nat. Rev. Immunol. 2008;8:218–230.
  2. Bahadori K., Doyle-Waters M.M., Marra C., Lynd L., Alasaly K., Swiston J., Fitz Gerald J.M. Economic burden of asthma: a systematic review. BMC Pulm. Med. 2009;9:24.
  3. Barnes P (1996) NO or no NO in asthma? Thorax 51:218–220.
  4. Bousquet J, Chanez P, Lacoste JY, et al. (1992) Asthma: a disease remodeling the airways. Allergy 47:3–11
  5. Redington AE, Springall DR, Ghatei MA, et al. (1997) Airway endothelin levels in asthma: influence of endobronchial allergen challenge and maintenance corticosteroid therapy. Eur    Respir J 10:1026–1032.
  6. Ozmen S, Tomac N, Uysal A, Arslan Z, Kuyucu N, Yoney A. Tuberculin responses in children with aller- gic diseases. Allergy 2002;57:1059-62.
  7. Manezes AM, Hallal PC, Perez-padila R, Jardim JR, Muiño A, Lopez MV, et al. Tuberculosis and airway obstruction: evidence from PLATINO study in Latin America. Eur Respir J 2007;30:1180-5.
  8. Jordan TS, Spencer EM, Davies P. Tuberculosis, bronchiectesis and chronic airflow obstruction. Res- pirology 2010;15:623-8.
  9. Expert panel report 3: guidelines for the diagnosis and management of asthma. Bethesda MD: National Institutes of Health, National Asthma Education and Prevention Program; 2007. NIH Publication No. 08-4051. Available from http:// nhlbi.nih.gov/guidelines/ asthma/asthgdln.pdf. Accessed February 29, 2008.
  10. Elkington P, Shiomi T, Breen R, Nuttall RK, Ugarte-Gil CA, et al. MMP-1 drives immuno-             pathology in human tuberculosis and transgenic mice. J Clin Invest. 2011;121:1827–1833.
  11. Hnizdo E, Singh T, Churchyard G. Chronic pulmonary function impairment caused by initial and recurrent pulmonary tuberculosis following treatment. Thorax. 2000;55:32–38.
  12. Chung KP, Chen JY, Lee CH, Wu HD, Wang JY, et al. Trends and predictors of changes in pulmonary function after treatment for pulmonary tuberculosis. Clinics (Sao Paulo) 2011;66:549–556.
  13. Pasipanodya JG, Miller TL, Vecino M, Munguia G, Garmon R, et al. Pulmonary impairment after tuberculosis. Chest. 2007;131:1817–1824.
  14. Ehrlich RI, White N, Norman R, Laubscher R, Steyn K, et al. Predictors of chronic bronchitis in South African adults. Int J Tuberc Lung Dis. 2004;8:369–376.
  15. Manezes AM, Hallal PC, Perez-padila R, Jardim JR, Muiño A, Lopez MV, et al. Tuberculosis and airway obstruction: evidence from PLATINO study in Latin Eur Respir J 2007;30:1180-5.
  16. Jordan TS, Spencer EM, Davies P. Tuberculosis, bronchiectesis and chronic airflow obstruction. Res- pirology 2010;15:623-8.

Corresponding Author

Dr Sunil Kumar Agrawal

Assistant Professor, Department of T.B. & Chest, Patna Medical College and Hospital, Patna, Bihar, India