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Category: Volume 07 Issue 09 September 2019
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Title: A Clinical Approach to a Case of Fever of Unknown Origin

Authors: Manoj Kumar, Omkar Singh, Surya Kamal Verma, Vishnu Rawat

 DOI: https://dx.doi.org/10.18535/jmscr/v7i9.39

Abstract

    

Introduction

Fever of unknown origin (FUO) is an intellectual and diagnostic challenge. Radically different approach is required in developing countries like India due to limited access to diagnostic facilities

Fever of unknown origin was first described by Petersdorf and Beeson1 in 1961, when study was conducted in 100 patients presenting with FUO. They established 3 criteria to define FUO2 –

  1. Minimum measured temperature of 38.3º C (101 º F) on several occasions.
  2. Fever over a period of at least 3 weeks.
  3. Diagnosis could not be reached after 3 outpatient visits or 3 days of hospitalization.

References

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  2. Finkelstein H. Habitual hyperthermia during recovery from scarlet fever.JAMA 1924;83(8)
  3. Arnow P ,Flaherty J.Fever of unknown origin .Lancet .1997;350 (9077):575 – 80
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  5. Mourad O, Palda V, Detsky A. A comprehensive evidence based approach to FUO. Arch inter med 2003 ;163:545
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  10. Knockaert DC,Vanneste LJ ,Vanneste SB,Bobaers HJ.Fever of unknown origin in the 1980s :an update of the diagnostic spectrum.Arch Intern med 1992;152:51-55
  11. Vargese G,Trowbridge P, Doherty T .Investigating and managing pyrexia of unknown origin in adults.BMJ 2010 ;341 :C 5470
  12. Roth AR ,Basello GM.Approach to the adult patient with fever of unknown origin.Am Fam Physician dec 1;68 (II):2223-8
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  14. Harrison’s principle of Internal Medicine 18th

Corresponding Author

Omkar Singh

Assistant Professor, Department of General Medicine, Autonomous State Medical College, Firozabad