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Category: Volume 07 Issue 09 September 2019
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Title: Study of Extended Spectrum Beta lactamase producing Klebsiella pneumoniae from various clinical samples at tertiary care Hospital, Jaipur

Authors: Pritam Kumar, Anshu Shastri, Vaishali Anandarshi, Dr Prasanna Gupta

 DOI: https://dx.doi.org/10.18535/jmscr/v7i9.15

Abstract

     

Background: The present study was done to detect Extended spectrum beta lactamase producing Klebsiella pneumoniae.

Introduction: Extended spectrum of beta lactamase (ESBL) producing Klebsiella pneumoniae, frequently resistant to many of the antimicrobial agents. Antimicrobial resistance is associated with high morbidity, mortality, increased length of hospitalization and cost of health care.

Materials and Methods: A total 63 Klebsiella pneumoniae strains were isolated from various clinical specimens. Out of total 63 isolates of Klebsiella pneumoniae, total 31 ESBL Positive Klebsiella pneumoniae founded. ESBL production confirmed by double disc synergy test (DDST) and by phenotypic confirmatory disc diffusion test (PCDDT).

Results: Out of total 63 isolates of Klebsiella pneumoniae, total 31(49.20%) ESBL Positive Klebsiella pneumoniae founded. Highest prevalence of ESBL producing Klebsiella pneumoniae was observed in case of Pus 80.0%, followed by ET 58.3%, Wound Swab & Swab 50% each, Sputum 45.4 %, Blood 42.8%, and urine 37.5%. A total 31 ESBL Positive Klebsiella pneumoniae found in which 22 in Male and 09 in Female.

Conclusion: This study demonstrate that production of ESBL in Klebsiella pneumoniae is directly linked to its high antimicrobial resistance especially resistance towards aminoglycosides and cephalosporins. It is necessary to follow proper strategies to detect and prevent the emergence of resistance for appropriate and effective treatment of infections caused by Klebsiella pneumoniae.

Keywords: Klebsiella pneumoniae, ESBL, Sensitivity, Resistance.

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Corresponding Author

Dr Prasanna Gupta        

Professor & Head, Department of Microbiology, National Institute of Medical Sciences & Research NIMS University Jaipur, 303121 (Rajasthan), India