Title: Coagulopathy on TB treatment naive HIV negative patients initiating anti TB medications at Thika level five hospital in Kenya
Authors: Nicholas Maina Muraguri, Dr Mutinda C. Kyama, Dr Kibet Shikuku
DOI: https://dx.doi.org/10.18535/jmscr/v7i8.87
Abstract
Coagulopathyis an abnormal bleeding disorder in which the blood’s ability to clot is impaired resulting to prolonged bleeding. Studies have shown a relationship between coagulopathy with many infections such as HIV viral infection after treatment.
Specific Objective: The study aims to determine the haemostatic changes in TB treatment naive HIV Negative patients initiating Anti TB Medications at Thika Level Five Hospital in Kiambu County of Kenya.
Design: Prospective study design was used by carrying out Prothrombin time (PT) and Alternate Partial Thromboplastin Time (aPTT) among TB patients before and after treatment.
Subjects: A total of 197 TB positive patients attending Thika level five hospitals TB clinic were recruited.
Method: With acquisition of eight milliliters of blood, samples were analyzed for Prothrombin Time Test and Activated Partial Thromboplastin Time Test prior to initiation of anti TB medication and after initiation of treatment.
Results: showed Significant differences in prothrombin time in age groups 42-49, 55-65 and above 66 years with p-values of 0.021, 0.000, and 0.000 respectively at 95 % confidence level before and after treatment. Age group above 66 years old showed significantly lower Activated Partial Thromboplastin Time after anti TB administration as compared to when they were naïve (p=0.000).
Conclusion: The study concluded that significant hemostatic changes occur after anti TB medication and recommended. Health Care providers should be aware of the haemostatic Changes that occur in TB Patients initiating treatment andcarry out these haemostatic tests and initiate treatment as soon asany problem is identified.
Keywords: Coagulopathy, Haemostatic changes, Prothrombin Time test, Activated Partial Thromboplastin time.
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