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Category: Volume 07 Issue 07 July 2019
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Title: A study to analyse the potentiality of Serum Uric Acid to use as a biomarker to detect Essential Hypertension Severity

Authors: Dr Mritunjay Kumar, Dr Smriti Kumari

 DOI: https://dx.doi.org/10.18535/jmscr/v7i7.170

Abstract

Aim: It has been seen that two third of patient who were having elevated blood pressure also unaware regarding their condition and as a result develop further complication. In a state like Bihar there was a need to correlate with a blood biomarkers which shed light on the underlying processes involved in the onset, development, and progression of essential hypertension. To analyse the potentiality of Serum uric acid to use as a biomarker to detect essential Hypertension Severity

Material: This was a single centre study. Total 120 patients were included in this trial where 60 subjects were with essential hypertension and rest 60 patients were without essential hypertension. This study was conducted at Diabetes centre in Bihar. Blood pressure was measured by a sphygmomanometer (Brand name Diamond) and pathological blood test was conducted at single NABL accredited pathology laboratory. Consent was taken from each participant. Current study was performed in accordance with the declaration of Helsinki.

Result: Subjects with essential hypertension also having high mean serum uric acid of 6.8±.2 mg/dl where as it was normal i.e. 4.2±0.2 mg/dl with control subjects who were not having any grade of hypertension (p≤0.005). It was observed that even duration of HTN is effect the level of serum uric acid. Subjects who were having HTN for more than 5 years were having serum uric acid of 7.1±0.3 mg/dl whereas subjects who were having HTN for less than 5 years were having serum uric acid of 4.5±0.2 mg/dl.

Conclusion: Serum uric acid can be used as a biomarker to detect essential hypertension severity and duration.

Keywords: Hypertension, uric acid, biomarker, severity and duration.

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Corresponding Author

Dr Mritunjay Kumar

Assistant Professor, Department of Medicine, Narayan Medical College and Hospital, Sasaram, Bihar, India