Title: Effect of Three Plant Extracts and Atorvastatin on Serum Lipids and Lipoproteins in Rats Fed High Cholesterol Diet
Authors: Kislay Awasthi, R.C. Gupta, Abbas Ali Mahdi
DOI: https://dx.doi.org/10.18535/jmscr/v7i7.100
Abstract
Introduction: To evaluate the relative efficacy of Gloriosa superba, Valeriana wallichii and Odenlandia corymbosa extracts and atorvastatin in correcting the dyslipidemia induced by feeding high cholesterol diet to rats.
Methods: The study was carried out on healthy male adult rats of Wistar strain. Dyslipidemia was induced by feeding them fructose-rich high fat diet (F-HFD). Gloriosa superba extract, Valeriana wallichii extract, Odenlandia corymbosa extract and atorvastatin were given orally for 30 days along with F-HFD to four different groups. Serum lipids and lipoproteins were measured.
Results: Feeding F-HFD for 30 days led to dyslipidemia in the form of raised serum cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol and free fatty acids. In the rats fed F-HFD + Valeriana wallichii extract, serum cholesterol, triglycerides and VLDL-cholesterol were significantly lower as compared to rats fed F-HFD alone. No such effect was seen in the rats given F-HFD + Gloriosa superba extract and F-HFD + Oldenlandia corymbosa extract. In the rats fed F-HFD + atorvastatin, serum lipids were significantly lower as compared to rats fed F-HFD alone and the effect was stronger than that of Valeriana wallichii.
Conclusion: Valeriana wallichii possesses anti-dyslipidemic activity but is not as effective as atorvastatin.
Keywords: Anti-dyslipidemic, Gloriosa superba, Valeriana wallichii, Odenlandia corymbosa.
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