Title: Vitamin D Deficiency in Pregnancy: Does Magnesium Play any Role?
Authors: Sanchayan Sinha, Souvik Konar, Sayantan Dasgupta, Soma Gupta
DOI: https://dx.doi.org/10.18535/jmscr/v7i7.70
Abstract
Introduction: Vitamin D is very important for fetal skeletal development in pregnancy. Deficiency of Vitamin D is quiet common among the pregnant women in our country. In the pathway of Vitamin D metabolism, magnesium is known to play an important role. It is cofactor of many enzymes involved in vitamin D metabolism & vitamin D binding protein. Some studies have suggested that both vitamin D and magnesium level decreases during pregnancy with adverse feto-maternal outcome.
Aims & Objectives: To find out levels of serum magnesium & vitamin D in both pregnant & non pregnant women & compare their levels for any significant difference &to find out whether any correlation exists between magnesium level and vitamin D level in pregnancy.
Materials & Methods: The study included the estimation of serum magnesium & vitamin D of 100 pregnant women (cases) & 100 age matched non pregnant women (controls). The values were tabulated & analysed by standard statistical method.
Result: Serum magnesium level was found to be lower in pregnancy (Mean ± SD is 1.83 mg/dl ± 0.61) than in non pregnant women (Mean ± SD is 1.94 mg/dl ± 0.64). Butthe decrease was not found to be significant (p < 0.05). However serum Vitamin D level was also found to be decreased in pregnancy (Mean ± SD is 14.74 ng/ml ± 5.83) than in non pregnant (Mean ± SD is 21.19 ng/ml ± 7.82) and the decrease was found to be significant (p < 0.05). Correlation coefficient between magnesium & Vitamin D was found to be 0.355.
Discussion: The decrease in Vitamin D level was found to be positively correlated with decrease in magnesium level in pregnancy. However the correlation coefficient is too small to establish any concrete correlation between them. Further in depth study is required to find out the cause of Vitamin D deficiency in pregnant women.
Keywords: Vitamin D, Magnesium, Pregnancy, Antepartum haemorrhage, Low birth weight, Birth asphyxia.
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