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Category: Volume 07 Issue 07 July 2019
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Title: Copper myeloneuropathy

Authors: Dr S.Vignesh, Dr Nagarajan K MD, Dr Anand P MD

 DOI: https://dx.doi.org/10.18535/jmscr/v7i7.69

Abstract

Myeloneuropathy is a frequently encountered condition and often poses a diagnostic challenge1. Myeloneuropathy arises from a variety of nutritional, toxic, metabolic, infective, inflammatory, and paraneoplastic disorders4. Vitamin B12, folic acid, copper, and vitamin E deficiencies may lead to myeloneuropathy resembling as that of subacute combined degeneration of the spinal cord6. Chikungunya viral infection has been shown to produce a syndrome similar to myeloneuropathy. Human immunodeficiency virus (HIV) infection may resemble subacute combined degeneration9. Magnetic resonance imaging (MRI) in subacute combined degeneration of the spinal cord typically reveals characteristic signal changes on T2-weighted images of the cervical spinal cord. Once myeloneuropathy diagnosis is suspected, all these patients should be subjected to a battery of tests11.  Vitamin B12, folic acid, vitamins A, D, E, and K serum levels along with levels of iron, methylmalonic acid, homocysteine, and calcium should be assessed13. Clinical features resembling myeloneuropathy along with the battery of biochemical tests often helps in establishing the correct diagnosis.

Keywords: Myeloneuropathy, Posterolateral syndrome, Demyelination.

References

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Corresponding Author

Dr S.Vignesh

Post-Graduate, Dept. of Medicine, Sri Manakula Vinayagar Medical College and Hospital (SMVMCH), Puducherry 605107, India