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Category: Volume 07 Issue 07 July 2019
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Title: Alteration of Lipid profile in patients of Rheumatoid arthritis in a Tertiary Care Hospital in Central India

Authors: Neha Solanki, Rohit Manyal, P.D. Sarkar

 DOI: https://dx.doi.org/10.18535/jmscr/v7i7.36

Abstract

Aim & Objective: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder characterized by symmetrical synovitis, progressive damage to the articular cartilage and the subchondral bone (1), as well as pain, fatigue, and disability (2).The purpose of this study was to investigate any significant correlation in the level of Lipid profile  and its association with severity of Rheumatoid arthritis

Material and Methods: Total 100 study subjects were divided into two groups, group A comprising 50 apparently healthy controls and group B comprising 50 patients of rheumatoid arthritis, which is further divided into subgroups on the basis of DAS 28 Score, group B1- remission, group B-2 included mild cases of rheumatoid arthritis, group B-3 of moderate & group B-4 of severe cases of rheumatoid arthritis.  Subjects were enrolled after applying all inclusion and exclusion criteria and written informed consent were taken. Serum Lipid profile p estimation were done by Transasia XL-640 Automated analyzer.

Results: The mean triglycerides in the control group was 121.28 ± 21.96 mg/dL while in the rheumatoid arthritis group was 156.32 ± 63.58 mg/dL. The mean VLDL in the control group was 24.26 ± 4.39 mg/dL while in the rheumatoid arthritis group was 31.26 ± 12.72 mg/dL. The difference was found to be statistically significant (p<0.05), showing a higher Triglycerides & VLDL in the rheumatoid arthritis group in comparison to the control group.

Conclusion: Patients with RA and chronic systemic inflammation have altered lipoprotein and apolipoprotein levels that may contribute to their higher risk of atherosclerosis

Keywords:Rheumatoid arthritis ,Triglyceride ,VLDL,Lipid profile.

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Corresponding Author

Rohit Manyal

Department of Biochemistry, MGM Medical College Indore, MP, India